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SML0961

Kobe0065

≥98% (HPLC)

Synonym(s):

N-(3-Chloro-4-methylphenyl)-2-[2,6-dinitro-4-(trifluoromethyl)phenyl]-hydrazinecarbothioamide

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Size/SKUAvailabilityPrice
5 mg
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$88.30

About This Item

Empirical Formula (Hill Notation):
C15H11ClF3N5O4S
CAS Number:
Molecular Weight:
449.79
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

$88.30


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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 15 mg/mL, clear

storage temp.

2-8°C

SMILES string

FC(F)(F)c1cc(c(c(c1)[N+](=O)[O-])NNC(=S)Nc2cc(c(cc2)C)Cl)[N+](=O)[O-]

InChI

1S/C15H11ClF3N5O4S/c1-7-2-3-9(6-10(7)16)20-14(29)22-21-13-11(23(25)26)4-8(15(17,18)19)5-12(13)24(27)28/h2-6,21H,1H3,(H2,20,22,29)

InChI key

KSJVAYBCXSURMQ-UHFFFAOYSA-N

Biochem/physiol Actions

Kobe0065 binds to Ras-GTP, blocking interactions with Raf kinase. Kobe0065 inhibits anchorage-dependent and -independent growth, blocks MEK/ERK activity and induces apoptosis in H-rasG12V transformed NIH3T3 cells. The compound Kobe0065 also inhibts tumor growth in SW480 colon cancer cell xenografts.
Kobe0065 is an inhibitor of Ras activity.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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This Item
SML0910SML0717Y102
description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

description

powder

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

200

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

room temp

storage temp.

-

solubility

DMSO: 15 mg/mL, clear

solubility

DMSO: 20 mg/mL, clear

solubility

H2O: 20 mg/mL, clear

solubility

H2O: insoluble, DMSO: 10 mg/mL

color

white to beige

color

light orange to dark orange

color

white to beige

color

white to yellow


Pictograms

Exclamation mark

Signal Word

Warning

Hazard Codes

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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