The minimum purity of this compound is 98% by HPLC. A review of recent lots indicates a typical purity of 99.5%. The purity is lot-specific and reported in the Certificate of Analysis. Please see the link below to review a sample or lot-specific Certificate:
https://www.sigmaaldrich.com/product/sigma/sml1354#product-documentation
SML1354
Tonabersat
≥98% (HPLC)
Synonym(s):
(3S-cis)-N-(6-Acetyl-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl)-3-chloro-4-fluoro-benzamide, N-[(3S,4S)-6-Acetyl-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-3-chloro-4-fluoro-benzamide, SB 220453, SB-220453
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| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Available to ship TODAYfromMILWAUKEE | $209.00 $177.65 |
25 mg | Available to ship TODAYfromMILWAUKEE | $796.00 |
About This Item
Empirical Formula (Hill Notation):
C20H19ClFNO4
CAS Number:
Molecular Weight:
391.82
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
$177.65
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Available to ship TODAYDetails
Quality Segment
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D -100 to -110°, c = 1 in methanol
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
2-8°C
SMILES string
CC(C1=CC=C2C([C@H](NC(C3=CC=C(F)C(Cl)=C3)=O)[C@H](O)C(C)(C)O2)=C1)=O
InChI
1S/C20H19ClFNO4/c1-10(24)11-5-7-16-13(8-11)17(18(25)20(2,3)27-16)23-19(26)12-4-6-15(22)14(21)9-12/h4-9,17-18,25H,1-3H3,(H,23,26)/t17-,18-/m0/s1
InChI key
XLIIRNOPGJTBJD-ROUUACIJSA-N
Biochem/physiol Actions
Tonabersat is a potent inhibitor of neuronal-glial gap junctions in trigeminal ganglion that inhibits cortical spreading depression (CSD) and neurogenic inflammation in animal models of migraine.
Tonabersat is a potent inhibitor of neuronal-glial gap junctions.
Tonabersat (SB-220453) exhibits anticonvulsant property. It is a member of the family of novel benzoylamino-benzopyran compounds. Tonabersat is used as a therapeutic for trigeminal nerve-induced neurovascular reflexes. In addition, it acts as a putative migraine prophylactic agent containing an unique stereospecific binding site in the brain.
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This Item | |||
|---|---|---|---|
| description ≥98% (HPLC) | description certified reference material, pharmaceutical secondary standard | description United States Pharmacopeia (USP) Reference Standard | description European Pharmacopoeia (EP) Reference Standard |
| form powder | form - | form - | form - |
| assay ≥98% (HPLC) | assay - | assay - | assay - |
| Quality Level 100 | Quality Level 300 | Quality Level - | Quality Level - |
| storage temp. 2-8°C | storage temp. -10 to -25°C | storage temp. - | storage temp. −20°C |
| solubility DMSO: 20 mg/mL, clear | solubility - | solubility - | solubility - |
| color white to beige | color - | color - | color - |
Signal Word
Warning
Hazard Codes
Precautionary Statements
Hazard Classifications
Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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