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SML1661

Bafilomycin A1

from Streptomyces griseus, ≥90% (HPLC), DMSO solution, V-ATPase inhibitor

Synonym(s):

BafA1

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0.1 mL
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$242.00

About This Item

Empirical Formula (Hill Notation):
C35H58O9
CAS Number:
88899-55-2
Molecular Weight:
622.83
UNSPSC Code:
12352200
NACRES:
NA.77
Form:
DMSO solution

$242.00

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Product Name

Bafilomycin A1 Ready Made Solution, 0.16 mM in DMSO, from Streptomyces griseus

biological source

Streptomyces griseus

Quality Segment

200

form

DMSO solution

concentration

0.16 mM in DMSO

shipped in

dry ice

storage temp.

−20°C

SMILES string

O1[C@@H]([C@H]([C@@H](C[C@]1(O)[C@H]([C@H](O)[C@@H]([C@H]2OC(=O)\C(=C\C(=C\[C@H]([C@H]([C@H](C\C(=C\C=C\[C@@H]2OC)\C)C)O)C)\C)\OC)C)C)O)C)C(C)C

InChI

1S/C35H58O9/c1-19(2)32-24(7)27(36)18-35(40,44-32)26(9)31(38)25(8)33-28(41-10)14-12-13-20(3)15-22(5)30(37)23(6)16-21(4)17-29(42-11)34(39)43-33/h12-14,16-17,19,22-28,30-33,36-38,40H,15,18H2,1-11H3/b14-12+,20-13+,21-16+,29-17-/t22-,23+,24-,25-,26-,27+,28-,30-,31+,32+,33+,35+/m0/s1

InChI key

XDHNQDDQEHDUTM-JQWOJBOSSA-N

General description

Bafilomycin A1, a macrolide antibiotic, belongs to the pleomacrolides family. It acts as a potent and selective inhibitor of vacuolar-type H+-ATPase. BafA1 can inhibit the viability of MG63 osteosarcoma cells. It can also stimulate mitochondrial dysfunction. BafA1 inhibits the proliferation of different types of cancer cells.

Application

Bafilomycin A1 has been used:
  • as an endosome acidification inhibitor to study the importance of endosome acidification in the extracellular vesicle uptake and cytosolic release of stably expressing NanoLuc luciferase-tagged Hsp70 (NLuc-Hsp70) in HeLa cells
  • as a vacuolar-type H+-ATPase (V-ATPase) inhibitor to study its effects on autophagic turnover of light chain 3 β (LC3-II) in mice
  • as an autophagy inhibitor to study its effects on primary rat liver sinusoidal endothelial cells (LSECs) defenestration

Biochem/physiol Actions

Bafilomycin A1 is a macrolide antibiotic.
Bafilomycin A1 is a macrolide antibiotic. Bafilomycin A1 acts as a potent and selective inhibitor of vacuolar-type H+-ATPase.
Bafilomycin A1 inhibits autophagy. It may exhibit anti-tumorigenic, anti-parasitic, and anti-neurodegenerative effects. Bafilomycin A1, found in lysosomes and endosomes prevents the acidification of these cell organelles. It also participates in blocking autophagosome-lysosome fusion and autolysosome acidification, steps necessary for maintaining the autophagic flux and cellular homeostasis.

Other Notes

Bafilomycin A1 solution is provided in concentration of 0.16 mM. Typical concentrations for use in cell culture are 50-100 nM.

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This Item
196000D2196SML1018
Bafilomycin A1 Ready Made Solution 0.16 mM in DMSO, from Streptomyces griseus

Sigma-Aldrich

SML1661

Bafilomycin A1 Ready Made Solution

Bafilomycin A1, Streptomyces griseus

Sigma-Aldrich

196000

Bafilomycin A1, Streptomyces griseus

DAF-FM solution 5 mM in DMSO, ≥97% (HPLC)

Sigma-Aldrich

D2196

DAF-FM solution

Cyclosporin A, Ready Made Solution 1 mg/mL in DMSO

Sigma-Aldrich

SML1018

Cyclosporin A, Ready Made Solution

description

0.16 mM in DMSO, from Streptomyces griseus

description

-

description

5 mM in DMSO, ≥97% (HPLC)

description

1 mg/mL in DMSO

form

DMSO solution

form

film

form

DMSO solution

form

DMSO solution

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

200

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

shipped in

dry ice

shipped in

-

shipped in

wet ice

shipped in

dry ice

biological source

Streptomyces griseus

biological source

-

biological source

-

biological source

-

concentration

0.16 mM in DMSO

concentration

-

concentration

-

concentration

1 mg/mL in DMSO

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

188.6 °F - closed cup

flash_point_c

87 °C - closed cup

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