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SML2235

CL075

≥98% (HPLC)

Synonym(s):

2-Propylthiazolo[4,5-c]quinolin-4-amine, 3M002

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Pack SizeSKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$118.00
25 mg

Available to ship TODAYfromMILWAUKEE

$455.00

About This Item

Empirical Formula (Hill Notation):
C13H13N3S
CAS Number:
256922-53-9
Molecular Weight:
243.33
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD09998898
Assay:
≥98% (HPLC)
Form:
powder

$118.00

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assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

[s]1c2c(nc1CCC)c(nc3c2cccc3)N

InChI

1S/C13H13N3S/c1-2-5-10-16-11-12(17-10)8-6-3-4-7-9(8)15-13(11)14/h3-4,6-7H,2,5H2,1H3,(H2,14,15)

InChI key

NFYMGJSUKCDVJR-UHFFFAOYSA-N

Application

CL075 has been used to activate the monocyte-derived dendritic cells (DCs) to demonstrate the ability of DCs to induce cell death.

Biochem/physiol Actions

CL075 is a selective agonist of Toll-like receptor-8 (TLR-8) with immunostimulant activity. It showed an EC50 value of 400nM for IRF-NFΚB stimulation in TLR8 compared to 4 μM for TLR7.
CL075 is a thiazoloquinolone derivative[1]. It might influence tumor development.[2]
Toll-like receptor-8 (TLR-8) agonist

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CL075 ≥98% (HPLC)

Sigma-Aldrich

SML2235

CL075

CL097 ≥98% (HPLC)

Sigma-Aldrich

SML2566

CL097

CGS 9895 ≥98% (HPLC)

Sigma-Aldrich

SML0376

CGS 9895

MLS1082 ≥98% (HPLC)

Sigma-Aldrich

SML2495

MLS1082

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear (warmed)

solubility

DMSO: >2 mg/mL (warmed)

solubility

DMSO: 2 mg/mL, clear

color

white to beige

color

white to very dark brown

color

light yellow to light brown

color

white to gray-brown

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000149593
0000149592
0000149593
0000149592
0000119614

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Cytotoxic activity of human dendritic cells induces RIPK1-dependent cell death
Varga Z, et al.
Immunobiology, 152032-152032 (2020)
Marianne W Mureith et al.
AIDS (London, England), 24(12), 1841-1848 (2010-07-01)
Chronic HIV-1 infection is characterized by high levels of persistent immune activation. Both HIV-1-encoded Toll-like receptor 7/8 (TLR7/8) ligands and TLR ligands encoded by products of microbial translocation have been implicated in inducing and sustaining immune activation in infected individuals
Heng Yang et al.
Zhonghua zhong liu za zhi [Chinese journal of oncology], 33(9), 643-648 (2012-02-22)
To observe the expression of Toll-like receptor 8 (TLR8) in human cervical cancer cell-line HeLa cells, and the effects of TLR8 agonist CL075 on the survival and proliferation of HeLa cells. PCR and RT-PCR were used to detect the expression

Global Trade Item Number

SKUGTIN
SML2235-5MG04061835303885
SML2235-25MG04061835303878

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