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SML2272

AZD-2098

≥98% (HPLC)

Synonym(s):

2,3-Dichloro-N-(3-methoxy-2-pyrazinyl)benzenesulfonamide, 2,3-Dichloro-N-(3-methoxypyrazin-2-yl)benzenesulfonamide, AZD 2098, AZD2098

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Pack SizeSKUAvailabilityPrice
25 mg

Estimated to ship onApril 27, 2026fromMILWAUKEE

$454.00
$385.90

About This Item

Empirical Formula (Hill Notation):
C11H9Cl2N3O3S
CAS Number:
Molecular Weight:
334.18
UNSPSC Code:
51111800
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

$385.90

List Price$454.00Save 15%
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Estimated to ship onApril 27, 2026Details


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assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=S(C1=CC=CC(Cl)=C1Cl)(NC2=NC=CN=C2OC)=O

InChI key

FLSMVCMSUNISFK-UHFFFAOYSA-N

Biochem/physiol Actions

AZD-2098 is an orally active, potent and selective CCR4 antagonist (pIC50 = 7.8/8.0/8.0/7.6 against CCL22 binding to human/mouse/rat/dog CCR4; inactive toward CXCR1/2 & CCR1/2b/5/7/8 at 10 μM) with little or no activity toward a panel of ∼120 receptors/enzymes. AZD-2098 effectively inhibits chemokine-induced cellular responses in vitro (pIC50 = 7.5 against CCL22-induced calcium influx in hCCR4-expressing CHO cells; pIC50 = 6.3 against CCL17- or CCL22-induced chemotaxis of primary human Th2 cells) and exhibits efficacy against antigen-induced inflammatory response among ovalbumin-sensitized rats in vivo (Emax = 7.5 μmol/kg p.o.; 1 h before and every 12 h after antigen challenge).
Orally active, potent and selective CCR4 antagonist with efficacy against antigen-induced inflammatory response in ovalbumin-sensitized rats in vivo.

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This Item
SML2819SML2226SML1184
assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 5 mg/mL, clear (warmed)

color

white to beige

color

white to beige

color

white to beige

color

white to beige


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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Discovery of AZD-2098 and AZD-1678, Two Potent and Bioavailable CCR4 Receptor Antagonists.
Nicholas Kindon et al.
ACS medicinal chemistry letters, 8(9), 981-986 (2017-09-28)



Global Trade Item Number

SKUGTIN
SML2272-25MG04061835507726
SML2272-5MG04061835507733

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