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SML2345

Rhynchophylline

From Uncaria rhynchophylla, ≥95% (HPLC), NMDA receptor antagonist, powder

Synonym(s):

(αE,1′R,6′R,7′S,8′aS)-6′-Ethyl-1,2,2′,3′,6′,7′,8′,8′a-octahydro-α-(methoxymethylene)-2-oxo- Spiro[3H-indole-3,1′(5′H)-indolizine]-7′-acetic acid methyl ester, (7β,16E,20α)-16,17-Didehydro-17-methoxy-2-oxo-corynoxan-16-carboxylic acid methyl ester, Mitrinermin, NSC 21731, Rhynchophyllin, Rhyncophylline, Mitrinermine

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Size/SKUAvailabilityPrice
5 mg
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$104.00
25 mg
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$420.00

About This Item

Empirical Formula (Hill Notation):
C22H28N2O4
CAS Number:
Molecular Weight:
384.47
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥95% (HPLC)
Form:
powder

$104.00


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Product Name

Rhynchophylline, ≥95% (HPLC)

biological source

Uncaria rhynchophylla

assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

shipped in

wet ice

storage temp.

−20°C

SMILES string

N21[C@H]([C@@]3(CC2)c4c(cccc4)NC3=O)C[C@@H]([C@H](C1)CC)\C(=C/OC)\C(=O)OC

InChI

1S/C22H28N2O4/c1-4-14-12-24-10-9-22(17-7-5-6-8-18(17)23-21(22)26)19(24)11-15(14)16(13-27-2)20(25)28-3/h5-8,13-15,19H,4,9-12H2,1-3H3,(H,23,26)/b16-13+/t14-,15-,19-,22+/m0/s1

InChI key

DAXYUDFNWXHGBE-KAXDATADSA-N

Biochem/physiol Actions

Rhynchophylline is a spirocyclic alkaloid isolated from Uncaria species that exibits numerous pharmacological activities including hypotensive, neuroprotective, anticonvulsive, antiepileptic, antiarrhythmic, anticoagulant, antispasmodic, and sedative. Rhynchophylline modulates voltage-gated K+ (Kv) channel slow inactivation in mouse neuroblastoma N2A cells. Also it acts as noncompetitive antagonists of NMDA receptor channels in Xenopus oocytes.

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This Item
54764SML0688A2846
description

≥95% (HPLC)

description

≥90% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC), solid

assay

≥95% (HPLC)

assay

≥90% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

solid

form

powder

form

solid

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

-

solubility

DMSO: 2 mg/mL, clear (warmed)

solubility

-

solubility

DMSO: 1 mg/mL, clear (warmed)

solubility

H2O: soluble

shipped in

wet ice

shipped in

-

shipped in

-

shipped in

-

color

white to beige

color

-

color

faintly pink to red

color

off-white to light tan


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pictograms

Skull and crossbones

signalword

Danger

hcodes

Hazard Classifications

Acute Tox. 2 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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