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SML2361

Kinesore

>97% (HPLC)

Synonym(s):

3,5-Dibromo-4-hydroxy-benzoic acid 2-[[2,5-dimethyl-1-(3-nitrophenyl)-1H-pyrrol-3-yl]methylene]hydrazide, 3,5-Dibromo-N′-{[2,5-dimethyl-1-(3-nitrophenyl)-1H-pyrrol-3-yl]methylene}-4-hydroxybenzohydrazide

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$107.00
$90.95
25 mg

Available to ship TODAYfromMILWAUKEE

$435.00

About This Item

Empirical Formula (Hill Notation):
C20H16Br2N4O4
CAS Number:
Molecular Weight:
536.17
UNSPSC Code:
31401503
NACRES:
NA.77
MDL number:
Assay:
>97% (HPLC)
Form:
powder

$90.95

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assay

>97% (HPLC)

form

powder

color

white to brown

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

Brc1c(c(cc(c1)C(=O)N\N=C\c2c([n](c(c2)C)c3cc(ccc3)[N+](=O)[O-])C)Br)O

InChI

1S/C20H16Br2N4O4/c1-11-6-14(12(2)25(11)15-4-3-5-16(9-15)26(29)30)10-23-24-20(28)13-7-17(21)19(27)18(22)8-13/h3-10,27H,1-2H3,(H,24,28)/b23-10+

InChI key

DUGCMEGLYHBMAR-AUEPDCJTSA-N

Biochem/physiol Actions

Kinesore is a cell penetrant and potent activator of kinesin-1 that induces kinesin light chain tetratricopeptide repeat domain-dependent kinesin-1 activation in the absence of organelle cargo-adaptor engagement. It inhibits kinesin-1 interaction with peptide fragment of organelle-specific cargo adaptors. Kinesore induces kinesin light chain conformational switch that causes remodeling of the microtubule network in cells.
cell penetrant and potent activator of kinesin-1 that causes remodeling of the microtubule network in cells

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This Item
SML0002I1911S8442
description

>97% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

assay

>97% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: >25 mg/mL

solubility

DMSO: >10 mg/mL

solubility

DMSO: 20 mg/mL, clear (warmed), H2O: insoluble

color

white to brown

color

red to brown

color

off-white to light brown

color

yellow to yellow-orange


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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