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SML2370

Dabigatran

≥95% (HPLC), Nonpeptide direct thrombin inhibitor, powder

Dabigatran

Synonym(s):

BIBR-953, N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-β-alanine

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$137.00
25 mg

Available to ship TODAYfromMILWAUKEE

$393.00

About This Item

Empirical Formula (Hill Notation):
C25H25N7O3
CAS Number:
Molecular Weight:
471.51
NACRES:
NA.77
UNSPSC Code:
12352200
MDL number:
Assay:
≥95% (HPLC)
Form:
powder

$137.00


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Product Name

Dabigatran, ≥95% (HPLC)

assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

0.1 M HCl: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

N=C(N)C(C=C1)=CC=C1NCC(N2C)=NC3=C2C=CC(C(N(CCC(O)=O)C4=NC=CC=C4)=O)=C3

InChI

1S/C25H25N7O3/c1-31-20-10-7-17(25(35)32(13-11-23(33)34)21-4-2-3-12-28-21)14-19(20)30-22(31)15-29-18-8-5-16(6-9-18)24(26)27/h2-10,12,14,29H,11,13,15H2,1H3,(H3,26,27)(H,33,34)

InChI key

YBSJFWOBGCMAKL-UHFFFAOYSA-N

Biochem/physiol Actions

Dabigatran is a nonpeptide direct thrombin inhibitor. It is an anticoagulant that functions by directly inhibiting both free and fibrin-bound thrombin. Dabigatron has been shown to prevent strokes in those with atrial fibrillation not caused by heart valve issues.
Nonpeptide, direct thrombin inhibitor

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This Item
SML2351SML1086SML1762
description

≥95% (HPLC)

description

≥98% (HPLC)

description

≥95% (HPLC)

description

≥98% (HPLC)

assay

≥95% (HPLC)

assay

≥98% (HPLC)

assay

≥95% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

solubility

0.1 M HCl: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: 20 mg/mL, clear

color

white to beige

color

white to beige

color

white to beige

color

, light yellow to dark orange


Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable



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Questions

  1. Hello, How to reconstitute dabigatran? Thank you

    1 answer
    1. This product can be solubilized in 0.1M HCl at > 2.0 mg/ml. The exact solubility of this product will be listed on the lot-specific Certificate of Analysis.

      Please navigate to the DOCUMENTATION section of the Product Detail Page to access a sample or lot specific Certificate under ‘Certificate of Analysis’:
      https://www.sigmaaldrich.com/product/sigma/sml2370#product-documentation

      Helpful?

Reviews

Active Filters

  1. Geneva
    • Review 1
    • Votes 0
    1 out of 5 stars.

    Too large bootle for 5 mg bottle

    Placing a 5 mg powder in a large glass bottle is really inconvenient. The power cannot be taken out at all.

    Helpful?

    1. Response from MilliporeSigma:

      Thank you for your review.
      SML2370 is supplied in a large enough vial for the product to be reconstituted in it. This allows the full amount to be reconstituted without losing powder while transferring. Please do not transfer powder out of the vial before reconstitution.
      We encourage customers who experience problems with our products to contact us for additional technical support. Please visit https://www.sigmaaldrich.com/US/en/support/customer-support to submit a Product Technical Inquiry.