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SML2494

Pralatrexate

≥98% (HPLC), DHFR inhibitor, powder

Synonym(s):

(2S)-2-[[4-[(1RS)-1-[(2,4-diaminopteridin-6-yl)methyl]but-3-ynyl]benzoyl]amino]pentanedioic acid, 10-propargyl-10-deazaaminopterin, N-(4-{1-[(2,4-diaminopteridin-6-yl)methyl]but-3-yn-1-yl}benzoyl)-L-glutamic acid, PDX

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Size/SKUAvailabilityPrice
5 mg
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$117.00
25 mg

Available to ship TODAYfromMILWAUKEE

$454.00
$385.90

About This Item

Empirical Formula (Hill Notation):
C23H23N7O5
CAS Number:
Molecular Weight:
477.47
NACRES:
NA.77
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

$117.00


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Product Name

Pralatrexate, ≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL

storage temp.

−20°C

SMILES string

O=C([C@@H](NC(C1=CC=C(C(CC(N=C23)=CN=C3N=C(N=C2N)N)CC#C)C=C1)=O)CCC(O)=O)O

InChI

1S/C23H23N7O5/c1-2-3-14(10-15-11-26-20-18(27-15)19(24)29-23(25)30-20)12-4-6-13(7-5-12)21(33)28-16(22(34)35)8-9-17(31)32/h1,4-7,11,14,16H,3,8-10H2,(H,28,33)(H,31,32)(H,34,35)(H4,24,25,26,29,30)/t14?,16-/m0/s1

InChI key

OGSBUKJUDHAQEA-WMCAAGNKSA-N

Biochem/physiol Actions

Potent DHFR inhibitor; antifolate; antineoplastic;
Pralatrexate is an antifolate that selectively enters cancer cells expressing reduced folate carrier type 1 (RFC-1). Pralatrexate potently inhibits DHFR (dihydrofolate reductase).

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This Item
SML3779M7824M8407
description

≥98% (HPLC)

description

≥98% (HPLC)

description

-

description

powder, BioReagent, suitable for cell culture, ≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

-

assay

≥98% (HPLC)

storage temp.

−20°C

storage temp.

-10 to -25°C

storage temp.

−20°C

storage temp.

−20°C

solubility

DMSO: 2 mg/mL

solubility

H2O: 2 mg/mL, clear

solubility

-

solubility

H2O: insoluble

color

white to beige

color

white to brown

color

-

color

-


Pictograms

Health hazard

Signal Word

Warning

Hazard Codes

Hazard Classifications

Repr. 2

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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