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SML2658

TT-10

≥98% (HPLC)

Synonym(s):

N2-Allyl-5-[(5-fluorothiophen-2-yl)carbonyl]thiazole-2,4-diamine, TAZ K, TAZ-K, TT 10, [4-Amino-2-(2-propen-1-ylamino)-5-thiazolyl](5-fluoro-2-thienyl)methanone

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Size/SKUAvailabilityPrice
5 mg
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$118.00
25 mg

Available to ship TODAYfromMILWAUKEE

$473.00
$402.05

About This Item

Empirical Formula (Hill Notation):
C11H10FN3OS2
CAS Number:
Molecular Weight:
283.35
UNSPSC Code:
41106609
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

$118.00


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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

NC1=C(C(C2=CC=C(S2)F)=O)SC(NCC=C)=N1

InChI

1S/C11H10FN3OS2/c1-2-5-14-11-15-10(13)9(18-11)8(16)6-3-4-7(12)17-6/h2-4H,1,5,13H2,(H,14,15)

InChI key

GVYPHJQPOHDZEI-UHFFFAOYSA-N

Biochem/physiol Actions

TAZ activator that promotes cardiomyocytes proliferation by activating YAP/TEAD-mediated transcription, as well as by exerting antioxidant and antiapoptotic activity.
TT-10 (TAZ K) is a TAZ (transcriptional coactivator with PDZ-binding motif) activator that promotes cardiomyocytes (CMs) proliferation (fold-increase by 10 μM TT-10 over untreated control = 5.2/rat CMs/40 hrs & 2.6/human iPSC-derived CMs/48 hrs) by activating YAP (YES-associated protein)/TEAD (transcriptional enhancer factor domain) complex-mediated transcription, as well as by exerting antioxidant and antiapoptotic activity. TT-10 ameliorates myocardial infarction-induced cardiac dysfunction in mice in vivo (10 mg/kg i.p.) at least in part via enhancing clonal expansion of existing cardiomyocytes with nuclear YAP expression.

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This Item
SML1725SML2472SML0870
description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

-

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 20 mg/mL, clear

color

white to beige

color

yellow to orange

color

white to pink

color

white to beige


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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