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SML2733

RLA8

≥98% (HPLC)

Synonym(s):

8-[3-Methoxy-5-[(1E)-2-(4-methoxyphenyl)ethenyl]phenoxy]octanoic acid

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$64.80
$55.08
25 mg

Available to ship TODAYfromMILWAUKEE

$263.00
$223.55

About This Item

Empirical Formula (Hill Notation):
C24H30O5
CAS Number:
Molecular Weight:
398.49
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
protect from light

$55.08

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Quality Segment

assay

≥98% (HPLC)

form

powder

storage condition

protect from light

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O(CCCCCCCC(=O)O)c1cc(cc(c1)\C=C\c2ccc(cc2)OC)OC

InChI

1S/C24H30O5/c1-27-21-13-11-19(12-14-21)9-10-20-16-22(28-2)18-23(17-20)29-15-7-5-3-4-6-8-24(25)26/h9-14,16-18H,3-8,15H2,1-2H3,(H,25,26)/b10-9+

InChI key

MNKZDYGBWDHRMX-MDZDMXLPSA-N

Biochem/physiol Actions

RLA8 is an orally available and potent agonist of peroxisome proliferator-activated receptors (PPARs)-α/γ/δ and G-protein-coupled receptor 40 (GPR40). RLA8 reverses the proregression of pathological changes such as hepatic lipid accumulation, steatosis, inflammation and fibrosis in mice models of nonalcoholic steatohepatitis (NASH). Also, it improves serum HDL cholesterol, reduce hepatic free fatty acid and triglyceride levels, and alleviate insulin resistance.
orally available and potent agonist for PPARs-α/γ/δ and GPR40 that exhibits efficacy to reverse nonalcoholic steatohepatitis and fibrosis

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This Item
P0022SML0364SML0393
description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

room temp

storage condition

protect from light

storage condition

protect from light

storage condition

-

storage condition

-

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: >20 mg/mL

solubility

DMSO: ≥5 mg/mL

solubility

DMSO: 5 mg/mL (warmed; clear solution)


Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable



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