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SML3009

Indiplon

≥98% (HPLC)

Synonym(s):

CL 285,489, CL 285489, CL-285,489, CL-285489, CL285,489, CL285489, N-Methyl-N-(3-(3-(thiophene-2-carbonyl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)acetamide, N-Methyl-N-[3-[3-(2-thienylcarbonyl)pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]acetamide, NBI 34060, NBI-34060, NBI34060

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Size/SKUAvailabilityPrice
5 mg

Estimated to ship onOctober 12, 2026fromMILWAUKEE

$91.40
25 mg

Estimated to ship onOctober 12, 2026fromMILWAUKEE

$370.00

About This Item

Empirical Formula (Hill Notation):
C20H16N4O2S
CAS Number:
325715-02-4
Molecular Weight:
376.43
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD09264193
Assay:
≥98% (HPLC)
Form:
powder

$91.40

Estimated to ship onOctober 12, 2026Details

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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

[s]1c(ccc1)C(=O)c2c3[n](nc2)C(=CC=N3)c4cc(ccc4)N(C)C(=O)C

InChI

1S/C20H16N4O2S/c1-13(25)23(2)15-6-3-5-14(11-15)17-8-9-21-20-16(12-22-24(17)20)19(26)18-7-4-10-27-18/h3-12H,1-2H3

InChI key

CBIAWPMZSFFRGN-UHFFFAOYSA-N

Biochem/physiol Actions

Indiplon (NBI 34060) is an orally active, high-affinity GABAA receptor positive allosteric modulator (PAM) with preferential labeling of alpha1 subunits-containing receptors (rat cerebellar/cerebral cortex membranes binding KD = 1.01/0.45 nM). Indiplon potentiates GABA-induced chloride conductance of cultured rat cortical neurons (EC50 = 11.6 nM vs 152 nM/630 nM) and exhibits sedative efficacy in mice (ED50 = 1 mg/kg/passive avoidance & 2.7 mg/kg/locomotor activity inhibition po.) and rats (ED50 = 2.5 mg/kg/locomotor activity inhibition & 3 mg/kg/vigilance impairment po.) in vivo. Indiplon shows greater affinity, in vitor and in vivo potency than zaleplon and zolpidem.
Orally active, high-affinity GABA(A) receptor positive allosteric modulator (PAM) with in vivo sedative-hypnotic efficacy.

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This Item
PHL82623
Indiplon ≥98% (HPLC)

Sigma-Aldrich

SML3009

Indiplon

Periplocin phyproof® Reference Substance

PHL82623

Periplocin

description

≥98% (HPLC)

description

phyproof® Reference Substance

form

powder

form

solid

assay

≥98% (HPLC)

assay

≥98.0% (HPLC)

Quality Level

100

Quality Level

-

storage temp.

2-8°C

storage temp.

-

solubility

DMSO: 2 mg/mL, clear

solubility

-

color

white to beige

color

-

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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