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SML3105

K-7174 dihydrochloride

≥98% (HPLC)

Synonym(s):

1,4-bis((E)-5-(3,4,5-Trimethoxyphenyl)pent-4-enyl)-1,4-diazepane dihydrochloride, K 7174 dihydrochloride, K7174 dihydrochloride, N,N?-bis-(E)-[5-(3,4,5-Trimethoxyphenyl)-4-pentenyl]homopiperazine dihydrochloride

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$98.10
25 mg

Available to ship TODAYfromMILWAUKEE

$316.00

About This Item

Empirical Formula (Hill Notation):
C33H48N2O6 · 2HCl
CAS Number:
Molecular Weight:
641.67
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated

$98.10


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Quality Segment

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

COC(C(OC)=C1)=C(C=C1/C=C/CCCN(CCC2)CCN2CCC/C=C/C3=CC(OC)=C(C(OC)=C3)OC)OC.[H]Cl.[H]Cl

InChI key

JKAQFPBRMVEHBD-CHBZAFCASA-N

Biochem/physiol Actions

K-7174 is a homopiperazine with dual GATA and proteasome inhibitory activtiy. K-7174 selective inhibts GATA-mediated gene regulations in cultures (10-30 μM; VCAM-1 expression in HUVECs or Epo suppression in Hep3B cells) and in vivo (30 mg/kg in mice via i.p. against IL-1beta- or TNF-alpha-induced anemia). K-7174 exhibits anti-myeloma activity in vitro (10-25 μM) and in vivo (50 mg/kg/day p.o. in mice) by targeting the active pockets of β1, β2 and β5 subunits of proteasome along hydrophobic grooves in the direction of the β7, β1 and β4 subunits in a manner distinct from that of bortezomib.
Orally active, dual GATA and proteasome inhibitor in vitro and in vivo.

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This Item
SML3185M2949SML2498
description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

room temp

storage temp.

2-8°C

solubility

H2O: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear (warmed)

solubility

H2O: 15 mg/mL, clear

solubility

H2O: 2 mg/mL, clear

storage condition

desiccated

storage condition

desiccated

storage condition

-

storage condition

desiccated


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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