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SML3143

CIGB-300 trifluoroacetate

≥95% (HPLC)

Synonym(s):

CIGB-325 trifluoroacetate, H-GRKKRRQRRRPPQ-βA-CWMSPRHLGTC-NH2 trifluoroacetate (βA = β-alanine; C15-C25 disulfide), H-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Pro-Gln-βAla-Cys-Trp-Met-Ser-Pro-Arg-His-Leu-Gly-Thr-Cys-NH2 trifluoroacetate (Cys15-Cys25 disulfide), P15-Tat trifluoroacetate

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Size/SKUAvailabilityPrice
1 mg

Available to ship TODAYfromMILWAUKEE

$298.00

About This Item

Empirical Formula (Hill Notation):
C127H216N54O29S3
CAS Number:
Molecular Weight:
3059.61
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥95% (HPLC)
Form:
film

$298.00


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Quality Segment

assay

≥95% (HPLC)

form

film

color

white to off-white

storage temp.

−20°C

Biochem/physiol Actions

CIGB-300 (P15-Tat) is a substrate-competitive casein kinase 2 inhibitor (CK2, CKII) composed of a membrane-permeant HIV-1 Tat protein transduction domain sequence (a.a. 48-60) N-terminal to a disulfide-bridged cyclic substrate peptide that inhibits against CK2-mediated substrate HPV-16 E7 phosphorylation in vitro. CIGB-300 exhibits cytotoxic effect in various cancer cultures (IC50 from 20 to 182 μM) via apoptosis induction and effectively inhibits TC-1 tumor growth in mice in vivo (48 μmol/200 μL/mouse via daily intratumoral injection).
Substrate-competitive casein kinase 2 (CK2, CKII) inhibitor with anti-cancer efficacy in cultures and in vivo.

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This Item
C8749SML2967SML2988
description

≥95% (HPLC)

description

≥95% (HPLC)

description

≥95% (HPLC)

description

≥95% (HPLC)

form

film

form

film or powder

form

film or powder

form

powder

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

color

white to off-white

color

colorless to light yellow

color

white to off-white

color

white to off-white


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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