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SRP2091

FGF-1 human

recombinant, expressed in insect cells, ≥85% (SDS-PAGE)

Synonym(s):

AFGF, ECGF, ECGF-beta, ECGFA, ECGFB, FGF-alpha, FGFA, GLIO703, HBGF1

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5 μg
Usually ships in 2 weeks.
$504.00

About This Item

NACRES:
NA.26
UNSPSC Code:
12352202

$504.00

Usually ships in 2 weeks.
​
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biological source

human

recombinant

expressed in insect cells

assay

≥85% (SDS-PAGE)

form

frozen liquid

mol wt

~19.2 kDa

packaging

pkg of 5 μg

storage condition

avoid repeated freeze/thaw cycles

concentration

500 μg/mL

color

colorless to clear

NCBI accession no.

NM_000800

UniProt accession no.

P05230

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... FGF1(2246)

General description

The gene FGF1 (fibroblast growth factor 1) encodes a member of the fibroblast growth factor (FGF) family. It encodes a pro-angiogenic protein that is ubiquitously expressed and is secreted via transmembrane translocation from the cells through a nonclassical secretory pathway in response to stress. It has the ability to permeate membranes composed of acidic phospholipids.

Application

FGF-1 (fibroblast growth factor 1) has been used as a growth factor to study the effect of FGF1 on early branching events in isolated endoderm obtained from embryonic mouse lung. It has also been used to study the neuroprotection effect of FGF1 on cerebellar granule neurons obtained from rats.

Biochem/physiol Actions

Acidic fibroblast growth factor (FGF-1) and basic fibroblast growth factor (FGF-2) are ubiquitous cytokines found in many tissues. They have effects on multiple cell types derived from mesoderm and neuroectoderm, including endothelial cells. FGF proteins are small peptides of 155 to 268 amino acid residues. The degree of sequence identity between different family members is 30-60 % in a "central domain" of approx. 120 amino acids. This domain confers to FGFs a common tertiary structure and the ability to bind to heparin. Secreted FGFs signal to target cells by binding and activating cell-surface tyrosine kinase FGF receptors (FGFRs; 6, 7). The function of FGFs and FGFRs during embryonic development and adult physiology has been addressed by gain- and loss-of-function experiments in several animal model organisms. These studies have shown that FGFs act as key regulators of developmental events.
The protein fibroblast growth factor 1, functions intracellularly to protect cells against stress. The protein functions as an angiogenic factor that participates in tissue repair, carcinogenesis, and maintenance of vasculature stability. Its expression is found to be upregulated in in patients with rheumatic arthritis. It serves as a prognostic biomarker in several cancers and a potential therapeutic target for patients with non-small cell lung cancer.

Physical form

Clear and colorless frozen liquid solution

Preparation Note

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

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This Item
F5542GF321F3685
FGF-1 human recombinant, expressed in insect cells, ≥85% (SDS-PAGE)

Sigma-Aldrich

SRP2091

FGF-1 human

Fibroblast Growth Factor-Acidic human FGF-Acidic, recombinant, expressed in E. coli, suitable for cell culture

Sigma-Aldrich

F5542

Fibroblast Growth Factor-Acidic human

FGF-acidic, Human Recombinant Animal Free

Sigma-Aldrich

GF321

FGF-acidic, Human Recombinant
Animal Free

Fibroblast Growth Factor-Basic FGF-Basic, from human, recombinant, expressed in E. coli, carrier free

Sigma-Aldrich

F3685

Fibroblast Growth Factor-Basic

description

recombinant, expressed in insect cells, ≥85% (SDS-PAGE)

description

FGF-Acidic, recombinant, expressed in E. coli, suitable for cell culture

description

-

description

FGF-Basic, from human, recombinant, expressed in E. coli, carrier free

assay

≥85% (SDS-PAGE)

assay

≥97% (SDS-PAGE)

assay

-

assay

≥97% (SDS-PAGE)

biological source

human

biological source

human

biological source

-

biological source

human

recombinant

expressed in insect cells

recombinant

expressed in E. coli

recombinant

-

recombinant

expressed in E. coli

form

frozen liquid

form

lyophilized powder

form

-

form

lyophilized powder

storage temp.

−70°C

storage temp.

−20°C

storage temp.

-10 to -25°C

storage temp.

−20°C

mol wt

~19.2 kDa

mol wt

15.5 kDa

mol wt

-

mol wt

16.0 kDa

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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