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Beta D-1 (47 aa) human

Name: Beta D-1 (47 aa) human
Brand: SIGMA
Price: 432 USD
Availability: InStock

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture

Synonym(s):

DEFB1, beta-Defensin-1

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Size/SKU	Availability	Price
20 μg	Usually ships in 2 weeks.	$432.00

About This Item

NACRES:

NA.32

UNSPSC Code:

12352202

Biological source:

human

Recombinant:

expressed in E. coli

Assay:

≥98% (HPLC), ≥98% (SDS-PAGE)

Form:

lyophilized

Mol wt:

5.0 kDa

Impurities:

<0.1 EU/μg endotoxin, tested

$432.00

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Properties

biological source

human

recombinant

expressed in E. coli

assay

≥98% (HPLC), ≥98% (SDS-PAGE)

form

lyophilized

mol wt

5.0 kDa

packaging

pkg of 20 μg

technique(s)

cell culture | mammalian: suitable

impurities

<0.1 EU/μg endotoxin, tested

color

white to off-white

UniProt accession no.

P60022

antibiotic activity spectrum

fungi, mycobacteria, viruses

mode of action

cell membrane | interferes

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... DEFB1(1672)

Description

General description

Chemical structure: peptide

Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The α-defensins are distinguished from the β-defensins by the pairing of their three disulfide bonds. To date, four human β-defensins have been identified; BD-1, BD-2, BD-3 and BD-4. β-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they are chemoattractant towards immature dendritic cells and memory T cells. The β-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence and, in the case of BD-1 (36a.a.), a propeptide region. b-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. β-defensins are 3-5 kDa peptides ranging in size from 33-47 amino acid residues. Recombinant human BD-1 is a 5.0 kDa protein containing 47 amino acid residues.

Biochem/physiol Actions

Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. Recombinant human BD-1 is a 5.0 kDa protein containing 47 amino acid residues.

Physical form

Lyophilized from 10 mM Sodium Citrate, pH 4.0.

Preparation Note

Centrifuge the vial prior to opening. Reconstitute in 10 mM Acetic Acid to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Other Notes

GNFLTGLGHR SDHYNCVSSG GQCLYSACPI FTKIQGTCYR GKAKCCK

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This Item	SRP3126	SRP3083	IL038
Sigma-Aldrich SRP3012 Beta D-1 (47 aa) human	Sigma-Aldrich SRP3126 NP-1 human	Sigma-Aldrich SRP3083 IL-1 beta human	Sigma-Aldrich IL038 Interleukin-1β Protein, Recombinant human
description recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture	description recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture	description Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture	description The recombinant human Interleukin-1beta protein (or IL-1beta protein) is a potent immuno-modulator which mediates a wide range of immune & inflammatory responses including the activation of B & T-cells.
assay ≥98% (HPLC), ≥98% (SDS-PAGE)	assay ≥98% (HPLC), ≥98% (SDS-PAGE)	assay ≥98% (HPLC), ≥98% (SDS-PAGE)	assay >98% (SDS-PAGE and HPLC)
recombinant expressed in E. coli	recombinant expressed in E. coli	recombinant expressed in E. coli	recombinant -
technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable
biological source human	biological source human	biological source human	biological source human
form lyophilized	form lyophilized	form lyophilized	form -
shipped in wet ice	shipped in wet ice	shipped in wet ice	shipped in dry ice

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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