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IL-3 human

Name: IL-3 human
Brand: SIGMA
Price: 441 USD
Availability: InStock

Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture

Synonym(s):

HCGF, MCGF (Mast cell growth factor), Multi-CSF, P-cell stimulation factor

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Size/SKU	Availability	Price
10 μg	Usually ships in 2 weeks.	$441.00

About This Item

NACRES:

NA.32

UNSPSC Code:

12352202

$441.00

Usually ships in 2 weeks.

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Properties

biological source

human

recombinant

expressed in E. coli

assay

≥98% (HPLC), ≥98% (SDS-PAGE)

form

lyophilized

potency

≤0.1 ng/mL ED₅₀

mol wt

15.0 kDa

packaging

pkg of 10 μg

technique(s)

cell culture | mammalian: suitable

impurities

<0.1 EU/μg endotoxin, tested

color

white to off-white

UniProt accession no.

P08700

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... IL3(3562)

Description

General description

IL3 (interleukin 3) is a haematopoietic growth factor, the gene for which is localized to human chromosome locus 5.
Recombinant human IL-3 is a 15.0 kDa globular protein containing 133 amino acid residues.

Biochem/physiol Actions

IL3 (interleukin 3) promotes the survival, proliferation and differentiation of haematopoietic progenitor cells. It also functions as an activator of basophils thus, resulting in significant increase in antigen and IgE-mediated release of cytokines and other mediators. Certain variants in this gene confer protection against malaria attack, and thus, this gene might play a role in the pathophysiology of falciparum malaria. SNP (single nucleotide polymorphism) rs40401 in this gene and smoking have a positive correlation with asthma in Japanese women. IL3 is involved in brain development and has a direct influence on the proliferation and survival of neural progenitor cell population, thereby also controlling human brain volume.

Physical form

Lyophilized with no additives.

Preparation Note

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a stabilizer (example 5% Trehalose) and store in working aliquots at -20°C to -80°C.

Other Notes

APMTQTTSLK TSWVNCSNMI DEIITHLKQP PLPLLDFNNL NGEDQDILME NNLRRPNLEA FNRAVKSLQN ASAIESILKN LLPCLPLATA APTRHPIHIK DGDWNEFRRK LTFYLKTLEN AQAQQTTLSL AIF

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This Item	SRP3275	SRP3091	SRP3287
Sigma-Aldrich SRP3090 IL-3 human	Sigma-Aldrich SRP3275 IL-33 human	Sigma-Aldrich SRP3091 IL-31 human	Sigma-Aldrich SRP3287 IL-34 human
description Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture	description Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)	description recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture	description recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE), ≥95% (HPLC)
biological source human	biological source human	biological source human	biological source human
recombinant expressed in E. coli	recombinant expressed in E. coli	recombinant expressed in E. coli	recombinant expressed in HEK 293 cells
technique(s) cell culture \| mammalian: suitable	technique(s) -	technique(s) cell culture \| mammalian: suitable	technique(s) -
assay ≥98% (SDS-PAGE), ≥98% (HPLC)	assay ≥98% (HPLC), ≥98% (SDS-PAGE)	assay ≥98% (SDS-PAGE), ≥98% (HPLC)	assay ≥95% (SDS-PAGE), ≥95% (HPLC)
form lyophilized	form lyophilized	form lyophilized	form lyophilized
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C

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Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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