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GDF-3 human

Name: GDF-3 human
Brand: SIGMA

Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

Synonym(s):

Vgr-2

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About This Item

NACRES:

NA.32

UNSPSC Code:

12352200

Form:

lyophilized

Assay:

≥98% (HPLC), ≥98% (SDS-PAGE)

Biological source:

human

Recombinant:

expressed in E. coli

Mol wt:

26.0 kDa

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Properties

biological source

human

recombinant

expressed in E. coli

assay

≥98% (HPLC), ≥98% (SDS-PAGE)

form

lyophilized

potency

100-150 ng/mL

mol wt

26.0 kDa

packaging

pkg of 20 μg

impurities

<0.1 EU/μg endotoxin, tested

color

white to off-white

UniProt accession no.

Q9NR23

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... GDF3(9573)

Description

General description

Unlike most TGF-β family members, GDF-3 and GDF-9 are not disulfide-linked dimers. GDF-3 is expressed in adult bone marrow, spleen, thymus, and adipose tissue. The expression of GDF-3 is upregulated in high-fat-fed wild-type FABP4/aP2 null mice and was associated with obesity, but not with the related hyperglycemia/hyperinsulinemia which characterizes Type 2 diabetes.

Biochem/physiol Actions

GDF-3 is a member of the TGF-β superfamily of growth and differentiation factors, and is highly homologous to GDF-9. Recombinant human GDF-3 is a 26.0 kDa non-disulfide-linked homodimer containing two 114 amino acid polypeptide chains.

Physical form

Lyophilized with no additives.

Preparation Note

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

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This Item	SRP3128	SRP3276	SRP3003
Sigma-Aldrich SRP3264 GDF-3 human	Sigma-Aldrich SRP3128 NT-3 human	Sigma-Aldrich SRP3276 SDF-1 ALPHA human	Sigma-Aldrich SRP3003 Activin A human
description Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)	description recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture	description Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)	description recombinant, expressed in E. coli, ≥97% (SDS-PAGE), ≥97% (HPLC), suitable for cell culture
biological source human	biological source human	biological source human	biological source human
recombinant expressed in E. coli	recombinant expressed in E. coli	recombinant expressed in E. coli	recombinant expressed in E. coli
assay ≥98% (HPLC), ≥98% (SDS-PAGE)	assay ≥98% (SDS-PAGE), ≥98% (HPLC)	assay ≥98% (HPLC), ≥98% (SDS-PAGE)	assay ≥97% (SDS-PAGE), ≥97% (HPLC)
form lyophilized	form lyophilized	form lyophilized	form lyophilized
mol wt 26.0 kDa	mol wt 13.6 kDa	mol wt 8.0 kDa	mol wt 26.0 kDa
UniProt accession no. Q9NR23	UniProt accession no. P20783	UniProt accession no. P48061	UniProt accession no. P08476

Storage Class

10 - Combustible liquids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

0811AFC326

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