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Progranulin human

Name: Progranulin human
Brand: SIGMA
Price: 393 USD
Availability: InStock

>95% (SDS-PAGE), recombinant, expressed in HEK 293 cells, lyophilized

Synonym(s):

Activation-inducible TNF-related ligand, PEPI, Proepithelin

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10 μg	Usually ships in 2 weeks.	$393.00

About This Item

UNSPSC Code:

12352202

NACRES:

NA.25

Biological source:

human

Recombinant:

expressed in HEK 293 cells

Assay:

>95% (SDS-PAGE)

Form:

lyophilized

Mol wt:

~65 kDa by SDS-PAGE

Impurities:

<0.1 EU/μg endotoxin, tested

$393.00

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Properties

Product Name

Progranulin human, recombinant, expressed in HEK 293 cells, untagged, >95% (SDS-PAGE)

biological source

human

recombinant

expressed in HEK 293 cells

conjugate

untagged

assay

>95% (SDS-PAGE)

form

lyophilized

mol wt

~65 kDa by SDS-PAGE

packaging

pkg of 10 μg

storage condition

avoid repeated freeze/thaw cycles

impurities

<0.1 EU/μg endotoxin, tested

color

white

UniProt accession no.

P28799

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... GRN(2896)

Description

General description

Progranulin (PGRN) is a cysteine-rich protein with 593-amino acids and has a molecular weight of ~68.5kDa. The PGRN gene, with one non-coding exon and 12 coding exons spanning 8kb of genomic DNA, is mapped to human chromosome 17q21. The encoded protein is characterized by seven granulin-like domains, which include 7.5 highly conserved tandem repeats of a rare 12 cysteinyl residues. PGRN is predominantly expressed in rapidly cycling epithelial cells, leukocytes, neurons, and chondrocytes.

Biochem/physiol Actions

Progranulin (PGRN) is a widely expressed pluripotent growth factor, which plays a crucial role in various processes such as development, cell cycle progression, cell motility, wound repair and inflammation. Additionally, It is also implicated in early embryogenesis, host defense, cartilage development and degradation. Mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). PGRN expression is associated with the development of various type of cancer such as breast cancer, ovarian carcinoma, and multiple myeloma. Overexpression of PGRN has been observed in neurodegenerative diseases such as microglia of Creutzfeldt-Jacob patients and in spinal cord of amyotrophic lateral sclerosis (ALS) patients.

Physical form

Lyophilized from 0.2 μm-filtered solution in PBS.

Preparation Note

Reconstitute with 100 μL deionized water.

Other Notes

Signal peptide and human progranulin (aa 1-593) is untagged. Reflects the native sequence with no additional aa.

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This Item	T3573	O4264	SRP8017
Sigma-Aldrich SRP8014 Progranulin human	Sigma-Aldrich T3573 RANK Ligand/TRANCE human	Sigma-Aldrich O4264 Osteopontin human	Sigma-Aldrich SRP8017 Progranulin rat
description recombinant, expressed in HEK 293 cells, untagged, >95% (SDS-PAGE)	description >90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder	description recombinant, expressed in NSO cells, ≥95% (SDS-PAGE), lyophilized powder, suitable for cell culture	description recombinant, expressed in HEK 293 cells, FLAG^® tagged, >95% (SDS-PAGE)
biological source human	biological source human	biological source human	biological source rat
recombinant expressed in HEK 293 cells	recombinant expressed in NSO cells	recombinant expressed in NSO cells	recombinant expressed in HEK 293 cells
assay >95% (SDS-PAGE)	assay >90% (SDS-PAGE)	assay ≥95% (SDS-PAGE)	assay >95% (SDS-PAGE)
form lyophilized	form lyophilized powder	form lyophilized powder	form lyophilized
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
impurities <0.1 EU/μg endotoxin, tested	impurities endotoxin, tested	impurities endotoxin, tested	impurities <0.1 EU/μg endotoxin, tested

Storage Class

10 - Combustible liquids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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