Skip to Content
MilliporeSigma

Key Documents

Skip To

T1568

Thrombopoietin human

recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture, ≥98% (SDS-PAGE and HPLC)

Promotion Available

Synonym(s):

MGDF, Megakaryocyte colony-stimulating factor, TPO, c-MPL ligand

Sign In to View Organizational & Contract Pricing.

Spend $500 — Save 5%; Spend $800 — Save 10%; Spend $1,600 — Save 22%*

Sign in to check eligibility. Shop Products

Select a Size

Change View
Size/SKUAvailabilityPrice
5 μg

Available to ship TODAYfromMILWAUKEE

$604.00

About This Item

CAS Number:
UNSPSC Code:
12352202
NACRES:
NA.32
MDL number:
Form:
lyophilized powder
Assay:
≥98% (SDS-PAGE and HPLC)
Biological source:
human
Recombinant:
expressed in E. coli
Mol wt:
18.6 kDa

$604.00

Save Up To 22%


Available to ship TODAYDetails


Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist


biological source

human

Quality Segment

recombinant

expressed in E. coli

assay

≥98% (SDS-PAGE and HPLC)

form

lyophilized powder

potency

≤1.0 ng/mL ED50

mol wt

18.6 kDa

packaging

pkg of 5 μg

storage condition

avoid repeated freeze/thaw cycles

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

UniProt accession no.

storage temp.

−20°C

Gene Information

human ... THPO(7066)

Application

TPO stimulates the proliferation and maturation of megakaryocytes and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor and acts as an important regulator of circulating platelets

Biochem/physiol Actions

TPO is a ligand for the c-mpl proto-oncogene (Mpl-L), a megakaryocyte colony stimulating factor and primary regulatory factor for megakaryocytopoiesis and thrombopoiesis. TPO is a humoral glycoprotein that stimulates growth and maturation of megakaryocytes and megakaryocytic colonies from bone marrow cultures.
Thrombopoeitin is a primary regulatory factor for megakaryocytopoiesis and thrombopoiesis. The mature form of TPO is a highly conserved glycoprotein, showing homology among various mammals. It is produced by liver and kidney cells. TPO stimulates growth and maturation of megakaryocytes and megakaryocytic colonies from bone marrow cultures. TPO binds and activates an 68-78 kDa glycoprotein receptor belonging to the GH family of cytokine receptors, a family that includes receptors to growth hormone (GH), erythropoietin (EPO), and prolactin (PRL). Like GH and EPO, TPO may bind to its receptor at two distinct sites, initiating receptor dimerization and activation. Analysis of mRNA indicates also the existence of a novel truncated and potentially soluble form of TPO receptor. The viral oncogene v-mlp of the myeloproliferative leukemia virus (MPLV) contains the gene sequence for the entire cytoplasmic and transmembrane domains and a portion of the extracellular domain of c-mlp (TPO receptor).

Physical form

Lyophilized from a 0.1 % TFA solution containing 250 μg bovine serum albumin

Analysis Note

The biological activity is measured in a cell proliferation assay using MO7e cells.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item
SRP3236S7901SRP3272
description

recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture, ≥98% (SDS-PAGE and HPLC)

description

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture

description

SCF, recombinant, expressed in E. coli, powder, suitable for cell culture

description

Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

assay

≥98% (SDS-PAGE and HPLC)

assay

≥98% (SDS-PAGE), ≥98% (HPLC)

assay

≥95% (SDS-PAGE)

assay

≥98% (SDS-PAGE), ≥98% (HPLC)

biological source

human

biological source

mouse

biological source

human

biological source

mouse

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

-

mol wt

18.6 kDa

mol wt

18.7 kDa

mol wt

monomer 18.6 kDa ((165 aa))

mol wt

18.7 kDa

form

lyophilized powder

form

lyophilized

form

powder

form

lyophilized


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library



Questions

Reviews

No rating value

Active Filters