The solubility of this product is tested at 1 mg/mL in water containing 0.1% TFA. While this material has not been tested specifically for use in Flow Cytometry, historical data indicates stock solutions may be further diluted with PBS containing 0.2% albumin for use in platelet flow cytometry assays.
T1573
Thrombin Receptor Activator Peptide 6
>95% (HPLC)
Synonym(s):
TRAP-6
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| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Check Cart for Availability | $490.00 |
About This Item
Empirical Formula (Hill Notation):
C34H56N10O9
CAS Number:
Molecular Weight:
748.87
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Form:
lyophilized
Assay:
>95% (HPLC)
$490.00
Check Cart for Availability
Quality Segment
assay
>95% (HPLC)
form
lyophilized
technique(s)
cell culture | mammalian: suitable
solubility
0.1% TFA: soluble, water: soluble
UniProt accession no.
storage temp.
−20°C
SMILES string
CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(O)=O
InChI
1S/C34H56N10O9/c1-18(2)13-23(30(49)40-22(11-8-12-39-34(37)38)29(48)44-26(33(52)53)16-27(36)46)42-31(50)24(14-19(3)4)43-32(51)25(41-28(47)21(35)17-45)15-20-9-6-5-7-10-20/h5-7,9-10,18-19,21-26,45H,8,11-17,35H2,1-4H3,(H2,36,46)(H,40,49)(H,41,47)(H,42,50)(H,43,51)(H,44,48)(H,52,53)(H4,37,38,39)/t21-,22-,23-,24-,25-,26-/m0/s1
InChI key
HAGOWCONESKMDW-FRSCJGFNSA-N
Gene Information
human ... F2R(2149)
General description
Thrombin Receptor Activator Peptide 6 (TRAP-6) protects astrocytes from cell death, which is associated with hypoglycemia. TRAP-6 induced aggregation and impaired adhesion to collagen under flow conditions.
Application
Thrombin Receptor Activator Peptide 6 has been used to activate platelets in vitro. It has also been used to downregulate hippo signaling and increase nuclear yes-associated protein (YAP).
Biochem/physiol Actions
Hexapeptide fragment of the thrombin receptor (residues 42-47).
Hexapeptide fragment of the thrombin receptor (residues 42-47). Shown to activate the thrombin receptor and cause platelet aggregation (EC50 = 0.8 μM).
Other Notes
Lyophilized from 0.1% TFA in H2O
1 of 1
This Item | |||
|---|---|---|---|
| description >95% (HPLC) | description The Thrombin Receptor Agonist, also referenced under CAS 137339-65-2, controls the biological activity of Thrombin Receptor. This small molecule/inhibitor is primarily used for Activators/Inducers applications. | description clone ATAP2, from mouse | description - |
| assay >95% (HPLC) | assay ≥95% (HPLC) | assay - | assay - |
| technique(s) cell culture | mammalian: suitable | technique(s) - | technique(s) immunocytochemistry: suitable, immunofluorescence: suitable, flow cytometry: suitable, western blot: suitable | technique(s) - |
| form lyophilized | form solid | form - | form lyophilized |
| UniProt accession no. | UniProt accession no. - | UniProt accession no. | UniProt accession no. - |
| Gene Information human ... F2R(2149) | Gene Information - | Gene Information human ... F2R(2149) | Gene Information - |
| storage temp. −20°C | storage temp. −20°C | storage temp. - | storage temp. −20°C |
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
PPE (personal protective equipment)
Eyeshields, Gloves, type N95 (US)
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I have bought T1573 Thrombin Receptor Activator Peptide 6 reagent. I have to use this reagent for platelet flowcytometry. This I have received in lyophilized powder form. From this reagent I have to prepare a solution. Tell me the dissolving agent?
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