The light chain for Product T1827, Monoclonal Anti-TBP antibody, clone 58C9 is a lambda light chain.
T1827
Anti -TBP antibody, Mouse monoclonal
clone 58C9, purified from hybridoma cell culture
Synonym(s):
Anti-GTF2D, Anti-GTF2DI, Anti-SCA17, Anti-TATA box binding protein, Anti-TFIID
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| Size/SKU | Availability | Price |
|---|---|---|
200 μL | Available to ship TODAYfromMILWAUKEE | $724.00 |
About This Item
Conjugate:
unconjugated
Clone:
58C9
Application:
IP, WB
Citations:
18
biological source
mouse
Quality Segment
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
58C9
mol wt
antigen ~42 kDa
species reactivity
Sf9 cell line, human, yeast, Drosophila melanogaster
technique(s)
immunoprecipitation (IP): suitable, western blot: 1-2 μg/mL using nuclear extracts of D.Mel cells
isotype
IgG2b
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
Drosophila melanogaster ... Tbp(37476)
human ... TBP(6908)
General description
Monoclonal Anti-TBP (mouse IgG2b isotype) is derived from the hybridoma 58C9 produced by the fusion of mouse myeloma cells and splenocytes from Swiss Webster mice immunized with Drosophila TFIID complex. Transcription factor IID (TFIID) complex contains the TATA-binding protein (TBP) and over a dozen of TBP-associated factors (TAFs).
TBP (TATA-binding protein) is encoded by the gene mapped to human chromosome 6q27. The encoded protein is a key constituent of RNA polymerase II transcription apparatus in eukaryotic cells.
TBP encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of tr
Immunogen
Drosophila TFIID complex.
Application
Monoclonal Anti-TBP antibody produced in mouse has been used in:
- immunoblotting
- co-immunoprecipitation
- immunohistochemistry
Biochem/physiol Actions
TBP facilitates promoter recognition with the help of the sequence-specific binding of the TATA element found in many promoters.
The TBP (TATA-binding protein) gene encodes a subunit of TFIIIB (transcription factor IIIB) complex and recognizes the TATA box in the DNA. Thus, it plays an important role in RNA polymerase II transcription machinery. TBP is known to induce stress granule formation in hepatitis B viral infection. Mutation in the gene is associated with the development of spinocerebellar ataxia 17 (SCA17).
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
1 of 1
This Item | |||
|---|---|---|---|
| description clone 58C9, purified from hybridoma cell culture | description clone 4D11, purified from hybridoma cell culture | description clone TTP6, tissue culture supernatant | description clone Mec-168, purified from hybridoma cell culture |
| antibody form purified from hybridoma cell culture | antibody form purified from hybridoma cell culture | antibody form tissue culture supernatant | antibody form purified from hybridoma cell culture |
| biological source mouse | biological source mouse | biological source mouse | biological source mouse |
| species reactivity Sf9 cell line, human, yeast, Drosophila melanogaster | species reactivity bovine, newt, chicken, human, monkey, mouse | species reactivity mouse, bovine, rat, dog, human, monkey | species reactivity rat, human, mouse |
| conjugate unconjugated | conjugate unconjugated | conjugate unconjugated | conjugate unconjugated |
| Gene Information Drosophila melanogaster ... Tbp(37476) | Gene Information human ... HNRNPL(3191) | Gene Information human ... ZFP36(7538) | Gene Information human ... MECP2(4204) |
| clone 58C9 | clone 4D11, monoclonal | clone TTP6, monoclonal | clone Mec-168, monoclonal |
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Storage Class
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Which light chain is used in Product T1827, Monoclonal Anti-TBP antibody, clone 58C9?
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