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Calcitonin salmon

Name: Calcitonin salmon
Brand: SIGMA
Price: 380 USD
Availability: InStock

≥97% (HPLC), powder

Synonym(s):

Thyrocalcitonin

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Size/SKU	Availability	Price
250 μg	Check Cart for Availability	$380.00
0.5 mg	Check Cart for Availability	$573.00
1 mg	Check Cart for Availability	$945.00

About This Item

Empirical Formula (Hill Notation):

C₁₄₅H₂₄₀N₄₄O₄₈S₂

CAS Number:

47931-85-1

Molecular Weight:

3431.85

NACRES:

NA.32

PubChem Substance ID:

24900157

UNSPSC Code:

51111800

EC Number:

256-342-8

MDL number:

MFCD00133859

Biological source:

synthetic (organic)

Form:

powder

Assay:

≥97% (HPLC)

$380.00

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Properties

biological source

synthetic (organic)

Quality Segment

200

sterility

non-sterile

assay

≥97% (HPLC)

form

powder

technique(s)

ligand binding assay: suitable

solubility

water: 1.00-1.04 mg/mL, clear, colorless

shipped in

ambient

storage temp.

−20°C

SMILES string

[H]N[C@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC1=O)C(C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N4CCC[C@H]4C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C(C)O)C(=O)N5CCC[C@H]5C(N)=O

InChI

1S/C145H240N44O48S2/c1-65(2)45-86(175-139(232)110(70(11)12)183-136(229)99-63-239-238-62-79(148)117(210)178-96(59-191)134(227)174-92(52-104(151)202)131(224)172-90(49-69(9)10)129(222)180-98(61-193)135(228)187-114(74(16)197)142(235)181-99)118(211)158-55-106(204)162-80(25-18-20-40-146)120(213)169-89(48-68(7)8)128(221)179-97(60-192)133(226)167-83(34-37-102(149)200)122(215)165-85(36-39-109(207)208)123(216)171-88(47-67(5)6)127(220)173-91(51-77-54-156-64-161-77)130(223)164-81(26-19-21-41-147)121(214)170-87(46-66(3)4)126(219)166-84(35-38-103(150)201)125(218)186-113(73(15)196)141(234)177-94(50-76-30-32-78(199)33-31-76)143(236)189-44-24-29-101(189)137(230)168-82(27-22-42-157-145(154)155)124(217)185-112(72(14)195)140(233)176-93(53-105(152)203)132(225)184-111(71(13)194)138(231)160-56-107(205)163-95(58-190)119(212)159-57-108(206)182-115(75(17)198)144(237)188-43-23-28-100(188)116(153)209/h30-33,54,64-75,79-101,110-115,190-199H,18-29,34-53,55-63,146-148H2,1-17H3,(H2,149,200)(H2,150,201)(H2,151,202)(H2,152,203)(H2,153,209)(H,156,161)(H,158,211)(H,159,212)(H,160,231)(H,162,204)(H,163,205)(H,164,223)(H,165,215)(H,166,219)(H,167,226)(H,168,230)(H,169,213)(H,170,214)(H,171,216)(H,172,224)(H,173,220)(H,174,227)(H,175,232)(H,176,233)(H,177,234)(H,178,210)(H,179,221)(H,180,222)(H,181,235)(H,182,206)(H,183,229)(H,184,225)(H,185,217)(H,186,218)(H,187,228)(H,207,208)(H4,154,155,157)/t71-,72-,73-,74-,75-,79+,80+,81+,82+,83+,84+,85+,86+,87+,88+,89+,90+,91+,92+,93+,94+,95+,96+,97+,98+,99+,100+,101+,110+,111+,112+,113+,114+,115+/m1/s1

InChI key

BBBFJLBPOGFECG-VJVYQDLKSA-N

Gene Information

human ... CALCR(799)

Description

Application

Calcitonin salmon can be used for calcitonin receptor/cAMP assay for assessing the presence of calcitonin receptors expressed by TRAP+ cells.The product can also be used as a test compound for studying as well as comparing the impact of calcitonin gene related peptide (CGRP) and salmon calcitonin (sCT) on gastric mucosal barrier in rats exposed to cold + restraint stress (CRS).

Biochem/physiol Actions

Calcitonin also refers as thyrocalcitonin is a 32 amino acid peptide hormone, which is present abundantly in seminal plasma compare to serum. It acts as a first messenger and hence regulate the the production of cAMP as well as mammalian sperm function. It may also facilitate the regulation of different isoforms of adenylyl cyclase. Additionally, salmon calcitonin stimulates the bone formation and inhibits the bone resorption in postmenopausal osteoporotic women.

Hypocalcemic hormone produced by the parafollicular C cells of the thyroid or by the ultimobranchial bodies of nonmammalian vertebrates. Decreases blood calcium and phosphate due to inhibition of resorption by osteoblasts and osteocytes.

Preparation Note

Calcitonin salmon dissolves in 1% acetic acid made in distilled water at a concentration of 1 mg/ml to yield a clear, colorless solution.

Other Notes

32 amino acid polypeptide, 8 of which are conserved across all species.

Lyophilized from 0.1% TFA in H2O

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1 of 1

This Item	1086200	C0200000	T3535
Sigma-Aldrich T3660 Calcitonin salmon	USP 1086200 Calcitonin salmon	C0200000 Calcitonin salmon	Sigma-Aldrich T3535 Calcitonin human
description ≥97% (HPLC), powder	description United States Pharmacopeia (USP) Reference Standard	description European Pharmacopoeia (EP) Reference Standard	description ≥97% (HPLC), powder
biological source synthetic (organic)	biological source -	biological source -	biological source synthetic (organic)
assay ≥97% (HPLC)	assay -	assay -	assay ≥97% (HPLC)
Quality Level 200	Quality Level -	Quality Level -	Quality Level 200
form powder	form lyophilized	form -	form powder
technique(s) ligand binding assay: suitable	technique(s) -	technique(s) -	technique(s) cell culture \| mammalian: suitable
shipped in ambient	shipped in -	shipped in -	shipped in ambient

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Pictograms

GHS06

Signal Word

Danger

Hazard Codes

H301

Precautionary Statements

P301 + P310 + P330

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

PPE (personal protective equipment)

Eyeshields, Faceshields, Gloves, type N95 (US)

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