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Anti-β-Tubulin III Antibody

Name: Anti-β-Tubulin III Antibody
Brand: SIGMA
Price: 395 USD

rabbit polyclonal

Synonym(s):

Anti-Tuj 1

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Size/SKU	Availability	Price
100 μg	Check Cart for Availability	$395.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD01323870

Conjugate:

unconjugated

Clone:

polyclonal

Application:

Citations:

$395.00

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Properties

Product Name

Anti-β-Tubulin III antibody produced in rabbit, ~1 mg/mL, affinity isolated antibody, buffered aqueous solution

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~50 kDa

species reactivity

human

concentration

~1 mg/mL

technique(s)

western blot: 1:500-1:1,000

UniProt accession no.

Q13509

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TUBB3(10381)
mouse ... Tubb3(22152)
rat ... Tubb3(246118)

Description

General description

Microtubules are heterodimeric proteins that comprise of α- and β-tubulins. β-tubulins have several different isotypes . β-Tubulin III is a marker for nerve cell differentiation, as well as for venous and lymphatic valves . Changes in β-tubulin III expression have been associated with medulloblastoma
Anti-tubulin antibodies are useful to study the localization of tubulin proteins. Anti-β-Tubulin III antibody is specific for β-Tubulin III in humans.

Tubulin β 3 class III (TUBB3) is mapped to human chromosome 16q24.3.

Immunogen

synthetic peptide corresponding to residues 151-165 of human β-Tubulin III.

Application

Anti-β-Tubulin III antibody is suitable for use in flow cytometry (1:200-1:500), immunohistochemistry (1:100-1:200), immunoblot (approx. 50kDa) and western blot (1:500-1:1,000).

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunocytochemistry (1 paper)
Immunofluorescence (1 paper)
Western Blotting (1 paper)

Biochem/physiol Actions

Missense mutations in the tubulin β 3 class III gene (TUBB3) impacts microtubule organisation in neuronal cells and contributes to neurological disorders. Mutations in TUBB3 is implicated in tubulopathies contributing to malformations in developing fetus.

Physical form

solution in phosphate buffered saline, containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	T2200	T5076	T8578
Sigma-Aldrich T3952 Anti-β-Tubulin III antibody produced in rabbit	Sigma-Aldrich T2200 Anti-β-Tubulin III antibody produced in rabbit	Sigma-Aldrich T5076 Anti-β-Tubulin Isotype III antibody, Mouse monoclonal	Sigma-Aldrich T8578 Anti-β-Tubulin III (neuronal) antibody, Mouse monoclonal
description ~1 mg/mL, affinity isolated antibody, buffered aqueous solution	description affinity isolated antibody, buffered aqueous solution	description clone SDL.3D10, purified from hybridoma cell culture	description ~1.0 mg/mL, clone 2G10, purified from hybridoma cell culture
biological source rabbit	biological source rabbit	biological source mouse	biological source mouse
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form purified immunoglobulin	antibody form purified from hybridoma cell culture
clone polyclonal	clone polyclonal	clone SDL.3D10, monoclonal	clone 2G10, monoclonal
species reactivity human	species reactivity rat, human, mouse	species reactivity mouse, rat, human, boar, bovine	species reactivity human, mouse, rat

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Storage Class

10 - Combustible liquids

WGK

nwg

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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