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T5293

Monoclonal Anti-β-Tubulin antibody produced in mouse

Name: Monoclonal Anti-β-Tubulin antibody produced in mouse
Brand: SIGMA
Price: 436 EUR

clone 2-28-33, ascites fluid

Sinonimo/i:

Anti-β-Tubulin Antibody

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Taglio della confezione	SKU	Disponibilità	Prezzo
100 μL		Per informazioni sulla disponibilità, contatta il Servizio Clienti.	436,00 €
0.2 mL		Per informazioni sulla disponibilità, contatta il Servizio Clienti.	566,00 €

Informazioni su questo articolo

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD00145892

Conjugate:

unconjugated

Clone:

2-28-33, monoclonal

Application:

IF, WB

Citations:

153

436,00 €

Per informazioni sulla disponibilità, contatta il Servizio Clienti.

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Servizio Tecnico

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Proprietà

biological source

mouse

Quality Segment

200

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

2-28-33, monoclonal

contains

15 mM sodium azide

species reactivity

Ciona intestinalis, rat, chicken, Caenorhabditis elegans, Strongylocentrotus purpuratus, bovine, human

enhanced validation

independent ( Antibodies)
Learn more about Antibody Enhanced Validation

technique(s)

indirect immunofluorescence: 1:1,000 using cultured chicken fibroblasts or cultured human foreskin fibroblasts, western blot: 1:100

isotype

IgG1

UniProt accession no.

Q9H4B7

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TUBB1(81027), TUBB2A(7280), TUBB2C(10383)
rat ... Tubb2(29212), Tubb2c(296554)

Descrizione

General description

β-Tubulin belongs to the subfamily of tubulin, which is the major building block of microtubules. β-tubulin has a molecular weight of 55kDa. β-Tubulin structure is characterized with core of two β-sheets enclosed by α-helices. It also contains an N-terminal domain with the guanine nucleotide-binding region, an intermediate domain with taxol-binding site, and a C-terminal domain that contains the binding surface for molecular motor proteins.Human β-tubulin consists of seven isoforms (βI (class I), βII (class II), βIII (class III), βIVa (class IVa), βIVb (class IVb), βV (class V), and βVI (class VI)).

Immunogen

sarkosyl-resistant ribbons from Strongylocentrotus purpuratus (sea urchin) sperm axonemes.

Application

Monoclonal Anti-β-Tubulin antibody produced in mouse has been used in western blotting and fluorescence immunocytochemical staining.

Biochem/physiol Actions

Mutation in the gene leads to various neuronal migration disorders such as lissencephaly, pachygyria and polymicrogyria malformations. B2702 peptide binds to β-tubulin and inhibits NK cell cytotoxicity and it influences microtubule polymerization, which damages cytoskeleton organization and chaperone-like activity of tubulin. β-1 tubulin also known as class VI or TUBB1, plays a vital role in platelet production, and is considered to be a potential biomarker candidate for immune thrombocytopenia (ITP).

The antibody recognizes the two major and one of the minor β‑tubulin isotypes of the free-living soil nematode C. elegans. It also binds to Sarkosyl-resistant ribbons from Strongylocentrotus purpuratus sperm axonemes, to neuronal axons of the larva of an ascidian (Ciona intestinalis) and to tubulin of chicken and mammals, cultured human fibroblasts, bovine and rat brain tissue. In C.elegans preparations, the antibody does not recognize tubulin that has been heat denatured in the presence of SDS and β-mercaptoethanol, though it is bound to tubulin separated on isoelectric focusing gels. It reacts with heat-denatured and reduced mammalian preparations in immunoblotting.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Questo articolo	T4026	T7816	T5201
Sigma-Aldrich T5293 Monoclonal Anti-β-Tubulin antibody produced in mouse	Sigma-Aldrich T4026 Monoclonal Anti-β-Tubulin antibody produced in mouse	Sigma-Aldrich T7816 Monoclonal Anti-β-Tubulin I antibody produced in mouse	Sigma-Aldrich T5201 Anti-β-Tubulin antibody, Mouse monoclonal
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
species reactivity Ciona intestinalis, rat, chicken, Caenorhabditis elegans, Strongylocentrotus purpuratus, bovine, human	species reactivity human, rat, frog, moth, mouse, plant, rabbit, chicken, bovine, wheat, sea urchin, hamster	species reactivity Xenopus, chicken, human, hamster, canine, mouse, bovine, rat	species reactivity human, rat, frog, moth, mouse, plant, rabbit, chicken, bovine, wheat, sea urchin, hamster
Gene Information human ... TUBB1(81027), TUBB2A(7280), TUBB2C(10383) rat ... Tubb2(29212), Tubb2c(296554)	Gene Information human ... TUBB(203068), TUBB1(81027), TUBB1(81027), TUBB1(81027), TUBB1(81027), TUBB2A(7280), TUBB2A(7280), TUBB2A(7280), TUBB2A(7280), TUBB2C(10383), TUBB2C(10383), TUBB2C(10383), TUBB2C(10383) mouse ... Tubb1(104068), Tubb1(104068), Tubb1(104068), Tubb1(104068), Tubb2a(22151), Tubb2a(22151), Tubb2a(22151), Tubb2a(22151), Tubb2c(227613), Tubb2c(227613), Tubb2c(227613), Tubb2c(227613) rat ... Tubb2(29212), Tubb2(29212), Tubb2(29212), Tubb2(29212), Tubb2c(296554), Tubb2c(296554), Tubb2c(296554), Tubb2c(296554)	Gene Information human ... TUBB(203068) mouse ... Tubb4(22153)	Gene Information human ... TUBB(203068), TUBB1(81027), TUBB1(81027), TUBB1(81027), TUBB1(81027), TUBB2A(7280), TUBB2A(7280), TUBB2A(7280), TUBB2A(7280), TUBB2C(10383), TUBB2C(10383), TUBB2C(10383), TUBB2C(10383) mouse ... Tubb1(104068), Tubb1(104068), Tubb1(104068), Tubb1(104068), Tubb2a(22151), Tubb2a(22151), Tubb2a(22151), Tubb2a(22151), Tubb2c(227613), Tubb2c(227613), Tubb2c(227613), Tubb2c(227613), Tubb3(22152) rat ... Tubb2(29212), Tubb2(29212), Tubb2(29212), Tubb2(29212), Tubb2c(296554), Tubb2c(296554), Tubb2c(296554), Tubb2c(296554)
antibody form ascites fluid	antibody form ascites fluid	antibody form ascites fluid	antibody form purified immunoglobulin
clone 2-28-33, monoclonal	clone TUB 2.1, monoclonal	clone SAP.4G5, monoclonal	clone TUB 2.1, monoclonal
biological source mouse	biological source mouse	biological source mouse	biological source mouse

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Classe di stoccaggio

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number

0000476622

0000426882

0000426883

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Articoli

Antibodies to Tubulins, including Centrosome-Associated ε-Tubulin

Microtubules of the eukaryotic cytoskeleton are composed of a heterodimer of α- and β-tubulin. In addition to α-and β-tubulin, several other tubulins have been identified, bringing the number of distinct tubulin classes to seven.

Contenuto correlato

Monoclonal Anti-B-Tubulin (T 5293)

Data Sheet - T5293

Numero articolo commerciale globale

SKU	GTIN
T5293-.2ML	04061838099921
T5293-100UL	04061838026927

Domande

Recensioni

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