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T5516

3,3′,5-Triiodo-L-thyronine sodium salt

γ-irradiated, powder, suitable for, suitable for cell culture

Synonym(s):

Liothyronine, O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine sodium salt, T3

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Size/SKUAvailabilityPrice
1 mg
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$104.00

About This Item

Empirical Formula (Hill Notation):
C15H11I3NNaO4
CAS Number:
55-06-1
Molecular Weight:
672.96
UNSPSC Code:
12352207
NACRES:
NA.77
PubChem Substance ID:
24900290
EC Number:
200-223-5
Beilstein/REAXYS Number:
8179867
MDL number:
MFCD00002594
Biological source:
synthetic (organic)
Form:
powder
Assay:
≥90% (HPLC)

$104.00

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biological source

synthetic (organic)

Quality Segment

sterility

γ-irradiated

assay

≥90% (HPLC)

form

powder

technique(s)

cell culture | mammalian: suitable

suitability

suitable for

shipped in

ambient

storage temp.

−20°C

SMILES string

[Na+].N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C([O-])=O

InChI

1S/C15H12I3NO4.Na/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22;/h1-4,6,12,20H,5,19H2,(H,21,22);/q;+1/p-1/t12-;/m0./s1

InChI key

SBXXSUDPJJJJLC-YDALLXLXSA-M

Gene Information

General description

3,3′,5′-Triiodo-L-thyronine (T3) is an endocrine hormone produced by the thyroid gland and is regarded as an active thyroid hormone at cellular level. Thyroxine (T4) serves as a precursor for T3 and is generated in extrathyroidal tissues.

Application

3,3′,5-Triiodo-L-thyronine sodium salt has been used:
  • as a supplement in colon organ culture media
  • to stimulate HuH-7 cells for analysing the hormonal influence on MBL synthesis
  • to study its effect on human growth hormone (GH) versus mouse GH expression in the presence of ′′intact′′ GH genes and in a common pituitary cell context

Biochem/physiol Actions

3,3′,5′-Triiodo-L-thyronine (T3) is a thyroid hormone that increases rates of proteins synthesis, stimulates the breakdown of cholesterol, and effects embryonic development. In cell culture, T3 regulates cell differentiation and protein expression. The interaction of T3 with nonhistone proteins in the chromatin initiates the thyroid hormone activity. Thyroid hormones regulate the differentiation and development of tissues and affect a number of metabolic processes. The level of circulating T3 hormone is reduced in hypothyroidism.

Physical form

powder-0 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw, solution stable 2-8 °C, 30 days

Preparation Note

Package size based on 3,3′,5-Triiodo-L-thyronine sodium salt content; vial may also contain inert salts, such as sodium chloride
To prepare 20 μg/ml stock solution: add 1 ml 1 N NaOH; gently swirl to dissolve; add 49 ml sterile medium.

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This Item
T63971368019L0700000
3,3′,5-Triiodo-L-thyronine sodium salt γ-irradiated, powder, suitable for, suitable for cell culture

Sigma-Aldrich

T5516

3,3′,5-Triiodo-L-thyronine sodium salt

3,3′,5-Triiodo-L-thyronine sodium salt powder, BioReagent, suitable for cell culture

Sigma-Aldrich

T6397

3,3′,5-Triiodo-L-thyronine sodium salt

USP

USP

1368019

Liothyronine Sodium

Liothyronine sodium European Pharmacopoeia (EP) Reference Standard

L0700000

Liothyronine sodium

description

γ-irradiated, powder, suitable for, suitable for cell culture

description

powder, BioReagent, suitable for cell culture

description

United States Pharmacopeia (USP) Reference Standard

description

European Pharmacopoeia (EP) Reference Standard

biological source

synthetic (organic)

biological source

synthetic

biological source

-

biological source

-

assay

≥90% (HPLC)

assay

≥95%

assay

-

assay

-

Quality Level

200

Quality Level

200

Quality Level

-

Quality Level

-

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

-

technique(s)

-

form

powder

form

powder

form

-

form

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

-

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Storage Class

11 - Combustible Solids

WGK

WGK 3

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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    Certificates of Analysis (COA)

    Lot/Batch Number
    0000284104
    0000285428
    0000317083
    022K8932
    013K8938

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