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T5516

3,3′,5-Triiodo-L-thyronine sodium salt

γ-irradiated, powder, suitable for, suitable for cell culture

Synonym(s):

Liothyronine, O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine sodium salt, T3

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Size/SKUAvailabilityPrice
1 mg

Available to ship TODAYfromMILWAUKEE

$100.00

About This Item

Empirical Formula (Hill Notation):
C15H11I3NNaO4
CAS Number:
55-06-1
Molecular Weight:
672.96
UNSPSC Code:
12352207
NACRES:
NA.77
PubChem Substance ID:
24900290
EC Number:
200-223-5
Beilstein/REAXYS Number:
8179867
MDL number:
MFCD00002594
Biological source:
synthetic (organic)
Form:
powder
Assay:
≥90% (HPLC)

$100.00

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biological source

synthetic (organic)

Quality Segment

200

sterility

γ-irradiated

assay

≥90% (HPLC)

form

powder

technique(s)

cell culture | mammalian: suitable

suitability

suitable for

shipped in

ambient

storage temp.

−20°C

SMILES string

[Na+].N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C([O-])=O

InChI

1S/C15H12I3NO4.Na/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22;/h1-4,6,12,20H,5,19H2,(H,21,22);/q;+1/p-1/t12-;/m0./s1

InChI key

SBXXSUDPJJJJLC-YDALLXLXSA-M

Gene Information

human ... THRA(7067), THRB(7068)
rat ... Thra(81812), Thrb(24831)

General description

3,3′,5′-Triiodo-L-thyronine (T3) is an endocrine hormone produced by the thyroid gland and is regarded as an active thyroid hormone at cellular level. Thyroxine (T4) serves as a precursor for T3 and is generated in extrathyroidal tissues.

Application

3,3′,5-Triiodo-L-thyronine sodium salt has been used:
  • as a supplement in colon organ culture media
  • to stimulate HuH-7 cells for analysing the hormonal influence on MBL synthesis
  • to study its effect on human growth hormone (GH) versus mouse GH expression in the presence of ′′intact′′ GH genes and in a common pituitary cell context

Biochem/physiol Actions

3,3′,5′-Triiodo-L-thyronine (T3) is a thyroid hormone that increases rates of proteins synthesis, stimulates the breakdown of cholesterol, and effects embryonic development. In cell culture, T3 regulates cell differentiation and protein expression. The interaction of T3 with nonhistone proteins in the chromatin initiates the thyroid hormone activity. Thyroid hormones regulate the differentiation and development of tissues and affect a number of metabolic processes. The level of circulating T3 hormone is reduced in hypothyroidism.

Physical form

powder-0 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw, solution stable 2-8 °C, 30 days

Preparation Note

Package size based on 3,3′,5-Triiodo-L-thyronine sodium salt content; vial may also contain inert salts, such as sodium chloride
To prepare 20 μg/ml stock solution: add 1 ml 1 N NaOH; gently swirl to dissolve; add 49 ml sterile medium.

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This Item
L0700000Y0000860T2376
3,3′,5-Triiodo-L-thyronine sodium salt γ-irradiated, powder, suitable for, suitable for cell culture

Sigma-Aldrich

T5516

3,3′,5-Triiodo-L-thyronine sodium salt

Liothyronine sodium European Pharmacopoeia (EP) Reference Standard

L0700000

Liothyronine sodium

Liothyronine for peak identification European Pharmacopoeia (EP) Reference Standard

Y0000860

Liothyronine for peak identification

L-Thyroxine ≥98% (HPLC)

Sigma-Aldrich

T2376

L-Thyroxine

description

γ-irradiated, powder, suitable for, suitable for cell culture

description

European Pharmacopoeia (EP) Reference Standard

description

European Pharmacopoeia (EP) Reference Standard

description

≥98% (HPLC)

biological source

synthetic (organic)

biological source

-

biological source

-

biological source

synthetic

assay

≥90% (HPLC)

assay

-

assay

-

assay

≥98% (HPLC)

Quality Level

200

Quality Level

-

Quality Level

-

Quality Level

200

form

powder

form

-

form

-

form

powder

technique(s)

cell culture | mammalian: suitable

technique(s)

-

technique(s)

-

technique(s)

cell culture | mammalian: suitable

storage temp.

−20°C

storage temp.

-

storage temp.

-

storage temp.

room temp

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Storage Class

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