Product T8552 has not been tested for any endotoxin levels, nor has it been cell culture tested.
T8552
Trichostatin A
From Streptomyces sp., ≥98% (HPLC), Histone deacetylase (HDAC) inhibitor, powder
Synonym(s):
TSA, [R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
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| Size/SKU | Availability | Price |
|---|---|---|
1 mg | Available to ship TODAYfromMILWAUKEE | $209.00 |
5 mg | Available to ship TODAYfromMILWAUKEE | $678.00 |
About This Item
Empirical Formula (Hill Notation):
C17H22N2O3
CAS Number:
Molecular Weight:
302.37
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Product Name
Trichostatin A, ≥98% (HPLC), from Streptomyces sp.
biological source
Streptomyces sp.
Quality Segment
assay
≥98% (HPLC)
form
powder
solubility
methanol: soluble 1.90-2.10 mg/mL, clear, colorless to faint yellow or tan, DMF: soluble, DMSO: soluble, H2O: insoluble, acetone: slightly soluble, acetonitrile: soluble, benzene: slightly soluble, chloroform: slightly soluble, ethanol: soluble, ethyl acetate: slightly soluble, lower alcohols: soluble
storage temp.
−20°C
SMILES string
C[C@H](\C=C(C)\C=C\C(=O)NO)C(=O)c1ccc(cc1)N(C)C
InChI
1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/m1/s1
InChI key
RTKIYFITIVXBLE-QEQCGCAPSA-N
Gene Information
human ... HDAC1(3065), HDAC4(9759), HDAC6(10013), HDAC8(55869)
mouse ... ENSMUSG00000061062(15181)
rat ... Hdac7a(84582)
General description
Application
Biochem/physiol Actions
Trichostatin A (TSA) inhibits histone deacetylase at nanomolar concentrations; resultant histone hyperacetylation leads to chromatin relaxation and modulation of gene expression. May be involved in cell cycle progression of several cell types, inducing cell growth arrest at both G and G/M phases; may induce apoptosis. Enhances the efficacy of anticancer agents that target DNA. Trichostatin A serves as an epigenetic modifier.
Trichostatin A inhibits histone deacetylase at nanomolar concentrations; resultant histone hyperacetylation leads to chromatin relaxation and modulation of gene expression.
Features and Benefits
This compound is a featured product for Apoptosis and Gene Regulation research. Discover more featured Apoptosis and Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Preparation Note
Trichostatin A is soluble in methanol at 1.90 - 2.10 mg/ml and yields a clear, colorless to faint yellow/tan solution. It is also soluble in DMSO, DMF, acetonitrile, ethanol and lower alcohols. Trichostatin A is sparingly soluble in chloroform, ethyl acetate, acetone, and benzene. However, it is insoluble in water.
1 of 1
This Item | |||
|---|---|---|---|
| description ≥98% (HPLC), from Streptomyces sp. | description A potent and reversible, cell-permeable inhibitor of histone deacetylase. | description ≥98% (HPLC), from Streptomyces rimosus | description ≥98% (HPLC), from Fusarium sp. |
| form powder | form lyophilized solid | form solid | form powder |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 300 | Quality Level 100 | Quality Level 200 | Quality Level 200 |
| storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C | storage temp. −20°C |
| solubility lower alcohols: soluble, DMF: soluble, benzene: slightly soluble, methanol: soluble 1.90-2.10 mg/mL, clear, colorless to faint yellow or tan, chloroform: slightly soluble, ethyl acetate: slightly soluble, H2O: insoluble, DMSO: soluble, acetonitrile: soluble, acetone: slightly soluble | solubility ethanol: 1 mg/mL, DMSO: 20 mg/mL, methanol: soluble | solubility DMSO: soluble 0.90-1.10 mg/mL, clear, colorless, H2O: moderately soluble, ethanol: moderately soluble, aqueous acid: moderately soluble, methanol: moderately soluble | solubility DMSO: soluble, H2O: insoluble, ethyl acetate: soluble, chloroform: soluble, acetone: soluble |
| Gene Information human ... HDAC1(3065), HDAC4(9759), HDAC6(10013), HDAC8(55869) | Gene Information - | Gene Information - | Gene Information - |
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Storage Class
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Has Product T8552, Trichostatin A been endotoxin tested?
1 answer-
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At what concentration can Product T8552, Trichostatin A, be used as an inhibitor of histone deacetylase?
1 answer-
Trichostatin A inhibits histone deacetylase at nanomolar concentrations. Additional information may be found in the literature references cited on the product detail page for T8552.
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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How can I solubilize Product T8552, Trichostatin A?
1 answer-
Trichostatin A is soluble in dimethyl sulfoxide (DMSO) and in ethanol, each at 1 mg/mL. It is also soluble in methanol at 2 mg/mL. It is insoluble in water. Additional solubility information can be found on the data sheet on our website.
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How should solutions of Trichostatin A, Product T8552, be stored?
1 answer-
Solutions at a concentration of 2 mg/mL in DMSO can be divided into aliquots and stored frozen at -20°C.
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What is the shelf life of Product No. T8552, Trichostatin A?
1 answer-
The product has a recommended retest date (similar to a shelf life date) of 2 years. The actual recommended retest date for each lot is on the Certificate of Analysis located at our website.
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