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T8694

TrkB/Fc Chimera human

>90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

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100 μg

Available to ship TODAYfromMILWAUKEE

$994.00
$844.90

About This Item

UNSPSC Code:
51111800
NACRES:
NA.32
MDL number:
MFCD03458837
Form:
lyophilized powder
Assay:
>90% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in NSO cells
Mol wt:
120-130 kDa by SDS-PAGE (reducing), calculated mol wt 71 kDa

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biological source

human

Quality Segment

200

recombinant

expressed in NSO cells

assay

>90% (SDS-PAGE)

form

lyophilized powder

potency

0.1-0.4 μg/mL ED50

mol wt

120-130 kDa by SDS-PAGE (reducing), calculated mol wt 71 kDa

packaging

pkg of 100 μg

storage condition

avoid repeated freeze/thaw cycles

technique(s)

western blot: suitable

impurities

endotoxin, tested

UniProt accession no.

Q16620

storage temp.

−20°C

Gene Information

human ... NTRK2(4915)

Application

TrkB/Fc Chimera human can be used in synaptoneurosome preparation and western blot analysis. Intracerebroventricular administeration of TrkB/Fc chimera human blocks TrkB ligand signaling and was used to study the role of BDNF in ATN response augmentation.

Biochem/physiol Actions

TrkB/Fc Chimera human consist of extracellular domain of human TrkB1 fused to histidine-tagged Fc region of human IgG1 by using a polypeptide linker. TrkB belongs to tyrosine kinase receptors family and facilitates the hippocampal development as well as regulating the synaptic plasticity that underlies long-term potentiation and learning. Brain derived neurotrophic factor (BDNF) and Neurotrophin 4 or 5 are preferred ligands for TrkB. Nevertheless it can also bind to NTF3/neurotrophin-3 that is less efficient in activating the receptor but regulates neuron survival through NTRK2.
Binds specifically to mediate neurotrophins BDNF and NT-4/5.
Member of the Trk family tyrosine kinase receptors. Binds specifically to mediate neurotrophins BDNF and NT-4/5.

Physical form

Lyophilized from 0.2 μm filtered solution in phosphate buffered saline.

Preparation Note

Reconstitute to 100 μg/mL in phosphate buffered saline.

Analysis Note

Inhibits BDNF-induced proliferation of TrkB transfected cells, BaF-TrkB-BD.

Other Notes

Extracellular domain of human TrkB fused to the C-terminal histidine-tagged Fc region of human IgG1.

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description

>90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

description

>90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture

description

>90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

description

>90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

recombinant

expressed in NSO cells

recombinant

expressed in NSO cells

recombinant

expressed in NSO cells

recombinant

expressed in NSO cells

biological source

human

biological source

human

biological source

mouse

biological source

human

technique(s)

western blot: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

-

technique(s)

-

assay

>90% (SDS-PAGE)

assay

>90% (SDS-PAGE)

assay

>90% (SDS-PAGE)

assay

>90% (SDS-PAGE)

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

mol wt

120-130 kDa by SDS-PAGE (reducing), calculated mol wt 71 kDa

mol wt

50-55 kDa by SDS-PAGE (reducing), calculated mol wt ~37.3 kDa

mol wt

monomer calculated mol wt 49.6 kDa, 60-65 kDa by SDS-PAGE (reducing)

mol wt

monomer calculated mol wt 48.6 kDa, 50-55 kDa by SDS-PAGE (reducing)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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