Unfortunately, the purified R and S forms are not available. This product is a racemic mixture.
T9025
Thioridazine hydrochloride
≥99%, D2 dopamine receptor antagonist
Synonym(s):
10-[2-(1-Methyl-2-piperidyl)ethyl]-2-(methylthio)-10H-phenothiazine hydrochloride
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| Size/SKU | Availability | Price |
|---|---|---|
5 g | Check Cart for Availability | $123.00 |
25 g | Check Cart for Availability | $497.00 |
About This Item
Empirical Formula (Hill Notation):
C21H26N2S2 · HCl
CAS Number:
Molecular Weight:
407.04
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
204-992-8
MDL number:
Assay:
≥99%
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Product Name
Thioridazine hydrochloride, ≥99%
Quality Segment
assay
≥99%
solubility
H2O: soluble 250 mg plus 5 ml of solvent, clear, colorless to faintly yellow, chloroform: soluble, diethyl ether: insoluble, ethanol: soluble, methanol: soluble
SMILES string
Cl.CSc1ccc2Sc3ccccc3N(CCC4CCCCN4C)c2c1
InChI
1S/C21H26N2S2.ClH/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(24-2)15-19(21)23;/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3;1H
InChI key
NZFNXWQNBYZDAQ-UHFFFAOYSA-N
Gene Information
human ... DRD2(1813), DRD3(1814), DRD4(1815), HTR2A(3356), HTR2C(3358)
Application
Thioridazine hydrochloride has been used as an intercalating agent for analyzing the integrity of double-stranded DNA (dsDNA) using square-wave voltammetry (SWV) techniques. Thioridazine hydrochloride has also been used as a positive control for the inhibition of hepatic enzyme cytochrome P4502D6 (CYP2D6) in human liver microsomes.
Biochem/physiol Actions
D2 dopamine receptor antagonist; phenothazine antipsychotic with reduced extrapyramidal side effects; Ca2+ channel blocker.
Preparation Note
250 mg of thioridazine hydrochloride is soluble in 5 ml of water and yields a clear, colorless to faint yellow solution. Thioridazine hydrochloride is also soluble in methanol, ethanol, and chloroform, but it is insoluble in ether.
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This Item | |||
|---|---|---|---|
| description ≥99% | description European Pharmacopoeia (EP) Reference Standard | description United States Pharmacopeia (USP) Reference Standard | description pharmaceutical secondary standard, certified reference material |
| assay ≥99% | assay - | assay - | assay - |
| Quality Level 100 | Quality Level - | Quality Level - | Quality Level 300 |
| solubility chloroform: soluble, diethyl ether: insoluble, H2O: soluble 250 mg plus 5 ml of solvent, clear, colorless to faintly yellow, methanol: soluble | solubility - | solubility - | solubility - |
| Gene Information human ... DRD2(1813), DRD3(1814), DRD4(1815), HTR2A(3356), HTR2C(3358) | Gene Information human ... DRD2(1813), DRD3(1814), DRD4(1815), HTR2A(3356), HTR2C(3358) | Gene Information human ... DRD2(1813), DRD3(1814), DRD4(1815), HTR2A(3356), HTR2C(3358) | Gene Information - |
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Signal Word
Warning
Hazard Codes
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
WGK
WGK 3
PPE (personal protective equipment)
dust mask type N95 (US), Eyeshields, Gloves
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