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Anti-Tropomyosin (Sarcomeric) antibody, Mouse monoclonal

Name: Anti-Tropomyosin (Sarcomeric) antibody, Mouse monoclonal
Brand: SIGMA
Price: 589 USD
Availability: InStock

clone CH1, purified from hybridoma cell culture

Synonym(s):

Monoclonal Anti-Tropomyosin (Sarcomeric) antibody produced in mouse, Anti-C15orf13, Anti-CMD1Y, Anti-CMH3, Anti-HEL-S-265, Anti-HTM-alpha, Anti-LVNC9, Anti-TMSA

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Size/SKU	Availability	Price
0.2 mL	Available to ship TODAYfromMILWAUKEE	$589.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD00149029

Conjugate:

unconjugated

Clone:

CH1, monoclonal

Application:

ARR, IHC (f), IHC (p), IP, WB

Citations:

$589.00

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Properties

biological source

mouse

Quality Segment

200

conjugate

unconjugated

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

CH1, monoclonal

contains

15 mM sodium azide

species reactivity

human, chicken, rat

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50 using sections of human tongue, immunohistochemistry (frozen sections): suitable using human and animal tissue sections, immunoprecipitation (IP): suitable, microarray: suitable, western blot: suitable using native preparations

isotype

IgG1

UniProt accession no.

P09493

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

chicken ... TPM1(396366)
human ... TPM1(7168)
rat ... Tpm1(24851)

Description

General description

Tropomyosin 1 (TPM1) is encoded by the gene mapped to human chromosome 15q22.2. The encoded protein belongs to the TPM protein family.

Immunogen

chicken muscle tropomyosin.

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)

Monoclonal Anti-Tropomyosin (sarcomeric) antibody produced in mouse has been used in immunofluorescence and immunohistochemistry.

Biochem/physiol Actions

The antibody recognizes an epitope on skeletal and cardiac tropomyosin. The antibody shows no reaction with denatured protein by immunoblotting. No cross-reactivity has been observed with smooth muscle or non-muscle tropomyosin.

Tropomyosin 1 (TPM1) is a potent tumor suppressor gene. It is expressed at low levels in various types of solid cancers including, oral squamous cell carcinoma (OSCC) and tongue squamous cell carcinoma. Mutation in the gene is associated with the development of hypertrophic cardiomyopathy. The encoded protein is involved in the regulation of actin-myosin interaction in striated muscles. Tropomyosin plays an essential role in Ca²⁺ -regulated contraction of cardiac muscle.

Physical form

Physical form: Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	T2780	SAB5702711	MAB2254
Sigma-Aldrich T9283 Anti-Tropomyosin (Sarcomeric) antibody, Mouse monoclonal	Sigma-Aldrich T2780 Monoclonal Anti-Tropomyosin antibody produced in mouse	Sigma-Aldrich SAB5702711 Anti-Tropomyosin 1 Antibody, clone 5Q2H6, Rabbit Monoclonal	Sigma-Aldrich MAB2254 Anti-Tropomyosin Antibody, clone 15D12.2
description clone CH1, purified from hybridoma cell culture	description clone TM311, ascites fluid	description -	description clone 15D12.2, from mouse
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
antibody form purified from hybridoma cell culture	antibody form ascites fluid	antibody form -	antibody form purified antibody
biological source mouse	biological source mouse	biological source rabbit	biological source mouse
species reactivity human, chicken, rat	species reactivity pig, chicken, bovine, rabbit, mouse, hamster, rat, human	species reactivity mouse, rat	species reactivity human, mouse
clone CH1, monoclonal	clone TM311, monoclonal	clone 5Q2H6, monoclonal	clone 15D12.2, monoclonal
Gene Information chicken ... TPM1(396366) human ... TPM1(7168) rat ... Tpm1(24851)	Gene Information bovine ... TPM1(281544) chicken ... TPM1(396366) human ... TPM1(7168) mouse ... Tpm1(22003) rat ... Tpm1(24851)	Gene Information human ... TPM1(7168)	Gene Information human ... TPM1(7168)

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Storage Class

12 - Non Combustible Liquids

WGK

nwg

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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