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T9701

TRAIL human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE and HPLC), lyophilized powder

Synonym(s):

Apo2 Ligand, Apo2L, TL2, TNF-related apoptosis-inducing ligand

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Size/SKUAvailabilityPrice
20 μg

Estimated to ship onMay 26, 2026fromMILWAUKEE

$768.00

About This Item

CAS Number:
2244730-93-4
UNSPSC Code:
12352200
NACRES:
NA.32
MDL number:
MFCD01867158
Form:
lyophilized powder
Assay:
≥98% (SDS-PAGE and HPLC)
Biological source:
human
Recombinant:
expressed in E. coli
Mol wt:
19.6 kDa, predicted mol wt ~21 kDa

$768.00

Estimated to ship onMay 26, 2026Details

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biological source

human

Quality Segment

200

recombinant

expressed in E. coli

description

extracellular domain

assay

≥98% (SDS-PAGE and HPLC)

form

lyophilized powder

mol wt

19.6 kDa, predicted mol wt ~21 kDa

technique(s)

immunofluorescence: suitable

impurities

endotoxin, tested

UniProt accession no.

P50591

storage temp.

−20°C

Gene Information

human ... TNFSF10(8743)

Application

TRAIL human has been used in immunofluorescence analyses, to study the delocalization of melanoma antigen-D2 in the nucleoplasm after a cellular stress.
Human TRAIL can be used as a selection agent for treating human cells for phenotypic enrichments.[1] The product can also be used in chemical transfection for identifying Small RNA Modulators of TRAIL-Induced Apoptosis Pathway by utilizing libraries of synthetic small interfering RNA (siRNA) and microRNAs (miRNA).[2]

Biochem/physiol Actions

TRAIL is a cytokine with anti-inflammatory, and antitumor activity. It is expressed in various cells including immune cells, vascular cells and adipocytes. TRAIL is associated with vascular endothelial cell protection.
TNF-related apoptosis-inducing ligand (TRAIL) is a type II transmembrane protein that belongs to TNF family. The product present in both soluble as well as membrane-bound form, can induce rapid apoptosis of various transformed cell lines but not the normal cells.[3] Additionally, the product can also induce apoptotic cell death in TRAIL-sensitive U343MG cells.
Type II transmembrane protein of the TNF superfamily. Ligand for apoptosis-inducing death receptors DR4 and DR5, decoy receptors DcR1 and DcR2, and osteoprotegerin. Approximately 28% amino acid sequence identity to FAS ligand. Human and mouse TRAIL share 65% sequence identity.

Physical form

Lyophilized from phosphate buffered saline

Analysis Note

The biological activity is determined by its ability to induce apoptotic cell death in TRAIL-sensitive LN-18 cells.

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This Item
T5694GF092616376
TRAIL human recombinant, expressed in E. coli, ≥98% (SDS-PAGE and HPLC), lyophilized powder

Sigma-Aldrich

T9701

TRAIL human

TRAIL human recombinant, expressed in NSO cells, >97% (SDS-PAGE), lyophilized powder

Sigma-Aldrich

T5694

TRAIL human

TRAIL Protein, Recombinant human Human TRAIL (TNF-Related Apoptosis Inducing Ligand), also called APO2 Ligand, is a cytotoxic protein which activates rapid apoptosis in tumor cells, but not in normal cells.

Sigma-Aldrich

GF092

TRAIL Protein, Recombinant human

TRAIL, Human, Recombinant, NSO cells

Sigma-Aldrich

616376

TRAIL, Human, Recombinant, NSO cells

assay

≥98% (SDS-PAGE and HPLC)

assay

>97% (SDS-PAGE)

assay

>98% (SDS-PAGE and HPLC)

assay

≥97% (SDS-PAGE)

biological source

human

biological source

human

biological source

human

biological source

-

technique(s)

immunofluorescence: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

-

recombinant

expressed in E. coli

recombinant

expressed in NSO cells

recombinant

expressed in E. coli

recombinant

expressed in NSO cells

form

lyophilized powder

form

lyophilized powder

form

solid

form

lyophilized

mol wt

19.6 kDa, predicted mol wt ~21 kDa

mol wt

24 kDa by SDS-PAGE, predicted mol wt ~21 kDa

mol wt

19.6 kDa

mol wt

-

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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