U3633
U 18666A
≥98% (HPLC), cholesterol synthesis inhibitor, powder
Synonym(s):
(3β)-3-[2-(Diethylamino)ethoxy]androst-5-en-17-one hydrochloride
Select a Size
| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Check Cart for Availability | $141.00 |
25 mg | Check Cart for Availability | $532.00 $452.20 |
About This Item
Product Name
U 18666A, powder
assay
≥98% (HPLC)
Quality Segment
form
powder
color
white to off-white
mp
195-196.5 °C (lit.)
solubility
H2O: 10 mg/mL≥
storage temp.
2-8°C
SMILES string
Cl[H].[H][C@@]12CC=C3C[C@H](CC[C@]3(C)[C@@]1([H])CC[C@]4(C)C(=O)CC[C@@]24[H])OCCN(CC)CC
InChI
1S/C25H41NO2.ClH/c1-5-26(6-2)15-16-28-19-11-13-24(3)18(17-19)7-8-20-21-9-10-23(27)25(21,4)14-12-22(20)24;/h7,19-22H,5-6,8-17H2,1-4H3;1H/t19-,20-,21-,22-,24-,25-;/m0./s1
InChI key
GZFYZYBWLCYBMI-MYZJJQSMSA-N
General description
Application
- as a competitive inhibitor of the Niemann-Pick disease, type C (NPC2) binding partner Niemann-Pick C1 (NPC1) to treat symbiotic and aposymbiotic adult Aiptasia to study the effect of global sterol transport inhibition
- in treating seminiferous tubules to study its effects on the localization pattern of VPS35-positive vesicles
- to study the U18666A treatment effects on early endosomes and late endosomes/multivesicular bodies (MVBs)
- as an NPC1 inhibitor to test its in vivo efficacy and study its effects on filovirus entry and infection
Biochem/physiol Actions
Preparation Note
1 of 1
This Item | |||
|---|---|---|---|
| description powder | description ≥98% | description ≥98% (HPLC) | description - |
| form powder | form powder | form powder | form powder |
| assay ≥98% (HPLC) | assay ≥98% | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 200 | Quality Level 200 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility H2O: 10 mg/mL≥ | solubility - | solubility H2O: 15 mg/mL, clear | solubility DMSO: 10 mg/mL, clear |
| color white to off-white | color - | color white to beige | color white to beige |
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
PPE (personal protective equipment)
Eyeshields, Gloves, type N95 (US)
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