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U8881

UCL 1684 ditrifluoroacetate hydrate

Synonym(s):

6,12,19,20,25,26-hexahydro- 5,27:13,18:21,24-Trietheno-11,7-metheno-7H-dibenzo[b,m][1,5,12,16]tetraazacyclotricosine-5,13-diium ditrifluoroacetate hydrate

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Size/SKUAvailabilityPrice
5 mg
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$316.00
$268.60
25 mg
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$1,250.00
$1,062.50

About This Item

Linear Formula:
(C34H30N4)2+ · (C2F3O2-)2 · xH2O
CAS Number:
Molecular Weight:
720.66 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

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color

white to off-white

Quality Segment

solubility

DMSO: 10 mg/mL

SMILES string

[H]O[H].FC(F)(C(O)=O)F.FC(F)(C(O)=O)F.C12=CC=CC=C1C(NCC3=CC=C(CNC4=CC=[N+](C5)C6=C4C=CC=C6)C=C3)=CC=[N+]2CC7=CC=CC5=C7

InChI

1S/C34H28N4.2C3H3F3O2.H2O/c1-3-10-33-29(8-1)31-16-18-37(33)23-27-6-5-7-28(20-27)24-38-19-17-32(30-9-2-4-11-34(30)38)36-22-26-14-12-25(13-15-26)21-35-31;2*4-3(5,6)1-2(7)8;/h1-20H,21-24H2;2*1H2,(H,7,8);1H2/b35-31+,36-32+;;;

InChI key

YROHEYZVNZITJN-DDVHGCDCSA-N

Application

UCL 1684 ditrifluoroacetate hydrate has been used for analyzing the mechanism for ammonium-mediated displacement of the protonated analyte from analyte-trifluoroacetic acid (TFA) ion-pair. UCL 1684 has also been used as a potassium channel inhibitor to study CNP (C-type natriuretic peptide)-induced relaxations in pig coronary arteries.

Biochem/physiol Actions

UCL 1684 is a potent non-peptide blocker of the apamin-sensitive Ca2+-activated K+ channel. It comprises two quinolinium rings and is similar to apamin arginine residue. UCL 1684 inhibits calcium-activated K current (Kslow) and modulates islet β-cell.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

UCL 1684 ditrifluoroacetate hydrate is soluble in water at 10 mg/ml.

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This Item
F9932D6196SML0125
description

-

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

solubility

DMSO: 10 mg/mL

solubility

DMSO: ≥20 mg/mL

solubility

H2O: ≥10 mg/mL

solubility

DMSO: ≥15 mg/mL

color

white to off-white

color

yellow

color

white to off-white

color

gray-brown


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)



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