The solution stability of this product has not been determined. However, historical data suggest that solutions in methanol are stable for several weeks when stored refrigerated and protect from light. Manufacturers of aqueous solutions in sodium chloride for therapeutic use indicate a shelf life of 6 months when stored refrigerated and protect from light.
V4629
(±)-Verapamil hydrochloride
≥99% (titration), powder, α1-adrenoceptor antagonist
Promotion Available
Synonym(s):
5-[N-(3,4-Dimethoxyphenylethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile hydrochloride
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| Size/SKU | Availability | Price |
|---|---|---|
1 g | Estimated to ship TODAYfromMILWAUKEE | $117.00 |
5 g | Estimated to ship TODAYfromMILWAUKEE | $468.00 |
10 g | Estimated to ship TODAYfromMILWAUKEE | $811.00 $689.35 |
About This Item
Linear Formula:
(CH3O)2C6H3CH2CH2N(CH3)(CH2)3C[C6H3(OCH3)2][CH(CH3)2]CN · HCl
CAS Number:
Molecular Weight:
491.06
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
205-800-5
MDL number:
Beilstein/REAXYS Number:
3647093
Assay:
≥99% (titration)
Form:
powder
$117.00
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Product Name
(±)-Verapamil hydrochloride, ≥99% (titration), powder
Quality Segment
assay
≥99% (titration)
form
powder
color
white
mp
142 °C (dec.) (lit.)
solubility
methanol: 50 mg/mL, ethanol: soluble
SMILES string
Cl.COc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC
InChI
1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H
InChI key
DOQPXTMNIUCOSY-UHFFFAOYSA-N
Gene Information
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779)
Application
Biochem/physiol Actions
α1-adrenoceptor antagonist; L-type calcium channel blocker.
α1-adrenoceptor antagonist; L-type calcium channel blocker. Blocks L-type Ca2+ channels in smooth and cardiac muscle, induces apoptosis of human primary and metastatic colon adenocarcinoma cells in vitro. Drug resistance reversal agent acting on Pgp, e.g. decrease renal tubule elimination of digoxin. Increases basal ATPase activity of Pgp. Substrate of Cyp3A4 and CYP2C6.
Features and Benefits
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
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This Item | |||
|---|---|---|---|
| description ≥99% (titration), powder | description A papaverine derivative that blocks Ca2+ channels (principally the L-type) in smooth and cardiac muscle cells. | description ≥98% (HPLC) | description ≥98% (HPLC), powder |
| form powder | form solid | form powder | form powder |
| assay ≥99% (titration) | assay ≥99% (perchloric acid titration) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| solubility ethanol: soluble, methanol: 50 mg/mL | solubility water: 70 mg/mL, methanol: 50 mg/mL, ethanol: soluble | solubility H2O: ≥30 mg/mL | solubility H2O: >10 mg/mL |
| color white | color white | color off-white to light yellow | color white |
| mp 142 °C (dec.) (lit.) | mp - | mp - | mp - |
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Aquatic Chronic 2
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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