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V8379

Human Vitronectin

from human plasma, powder, suitable for cell culture

Synonym(s):

Serum spreading factor

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Size/SKUAvailabilityPrice
50 μg

Available to ship TODAYfromMILWAUKEE

$494.00

About This Item

CAS Number:
83380-82-9
UNSPSC Code:
12352202
NACRES:
NA.75
MDL number:
MFCD00132575
Biological source:
human plasma
Form:
lyophilized powder
Technique(s):
cell culture | mammalian: suitable
Mol wt:
A subunit 75 kDa, B subunit 65 kDa

$494.00

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Product Name

Vitronectin from human plasma, lyophilized powder, BioReagent, suitable for cell culture

biological source

human plasma

Quality Segment

300

product line

BioReagent

form

lyophilized powder

mol wt

A subunit 75 kDa, B subunit 65 kDa

packaging

pkg of 50 μg

technique(s)

cell culture | mammalian: suitable

surface coverage

0.1 μg/cm2

solubility

water: soluble 0.050 mg/mL, clear, colorless

UniProt accession no.

P04004

shipped in

ambient

storage temp.

2-8°C

Gene Information

human ... VTN(7448)

Application

Vitronectin can be used with cells with integrin receptors that bind vitronectin, including platelets, endothelial cells, melanoma cells, and osteosarcoma. It is recommended as a cell culture substratum at 0.1 μg/cm2. Optimal conditions for attachment depend on cell line and application.

Biochem/physiol Actions

Vitronectin binds to glycosaminoglycans, is incorporated as an inhibitor to the membrane cytolytic attack complex of the complement system, has interaction with thrombin and antithrombin III during coagulation, and may play a role in the coagulation pathway.

Preparation Note

This product is supplied as a cell culture tested lyophilized powder from buffered saline. It is recommended to use polypropylene vessels during handling, due to the strong affinity of vitronectin for hydrophilic surfaces. Reconstitution of this product can be done with 1 mL of water per vial. The stock solution should then be filter-sterilized using a 0.2μm membrane and aliquoted and frozen for long term storage.

Other Notes

Vitronectin is a glycoprotein present in plasma and tissues, and is one of the major cell adhesion proteins, along with fibronectin, in plasma. The N-terminal residues of vitronectin are identical to somatomedin B and are followed by an R-G-D sequence that interacts with a specific cell-surface receptor. The central domain of vitronectin is enriched with hydrophobic residues. Closer to the C-terminus, it has an arginine rich region that allows for heparin binding activity.

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
The lyophilized product should be stored desiccated at 2-8°C. Under these conditions it is stable for at least 2 years. Aliquots should be stored at -20°C or -70°C, but repeated freezing and thawing should be avoided.

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Vitronectin

description

lyophilized powder, BioReagent, suitable for cell culture

description

lyophilized powder, BioReagent, suitable for cell culture

description

recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE), ≥95% (HPLC), suitable for cell culture

description

from human plasma, suitable for cell culture, solution

biological source

human plasma

biological source

rat plasma

biological source

human

biological source

human plasma

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

Quality Level

300

Quality Level

200

Quality Level

200

Quality Level

100

mol wt

A subunit 75 kDa, B subunit 65 kDa

mol wt

75 kDa

mol wt

52.2 kDa (calculated)

mol wt

75 kDa

form

lyophilized powder

form

lyophilized powder

form

lyophilized

form

solution

Gene Information

human ... VTN(7448)

Gene Information

rat ... Vtn(29169)

Gene Information

human ... VTN(7448)

Gene Information

human ... VTN(7448)

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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