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Merck

RRM1

ribonucleotide reductase M1

Sinonimi:
R1, RIR1, RR1
Specie:
ID UniProtKB:
ID gene:
  • Human(6240) Summary: This gene encodes one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region. [provided by RefSeq, Jul 2008]
  • Mouse(20133) ribonucleotide reductase M1
  • Rat(685579) ribonucleotide reductase M1
  • chicken(419081) ribonucleotide reductase M1
  • Zebrafish(30740) ribonucleotide reductase M1 polypeptide
  • dog(476823) ribonucleotide reductase M1
  • cow(505537) ribonucleotide reductase M1
  • Horse(100053126) ribonucleotide reductase M1
  • domestic cat(101097343) ribonucleotide reductase M1
  • Domestic Rabbit(100345823) ribonucleotide reductase M1
  • sheep(101116171) ribonucleotide reductase M1
  • naked mole-rat(101708047) ribonucleotide reductase M1
  • domestic guinea pig(100728488) ribonucleotide reductase M1

Custom & Knockdown Gene Products

Antibodies

Numero di prodotto
Descrizione
Reattività con
Applicazione
Anti-RRM1 Antibody, clone 1E20 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reattività con
human, monkey
Applicazione
affinity binding assay
flow cytometry

immunohistochemistry

western blot
Anti-RRM1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reattività con
human
Applicazione
immunohistochemistry
Anti-RRM1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reattività con
human
Applicazione
immunofluorescence
immunohistochemistry

Small Molecule - Inhibitor

Numero di prodotto
Descrizione
Specie
Idrossiurea, United States Pharmacopeia (USP) Reference Standard,
Specie
human
Idrossiurea, European Pharmacopoeia (EP) Reference Standard,
Specie
human
Idrossiurea, British Pharmacopoeia (BP) Reference Standard,
Specie
human
Idrossiurea, 98%, powder,
Specie
human
Gemcitabine hydrochloride, ≥98% (HPLC),
Specie
human

esiRNA

Numero di prodotto
Descrizione
Specie
MISSION® esiRNA, targeting human RRM1,
Specie
human
MISSION® esiRNA, targeting mouse Rrm1,
Specie
mouse