[Relationship between salivary lipid peroxidation and the strategy of local dichloran gel treatment for periodontitis].

The effects of dicloran gel in combination with antibiotics on salivary lipid peroxidation were evaluated in 18 patients aged 23-68 years with chronic generalized rapidly progressing periodontitis. Lipid peroxidation and activity of antioxidant systems surpassed the normal values 2-4-fold in periodontitis patients before treatment. After therapy with metrogil-dent these parameters decreased (p < 0.05). Injection of dicloran gel before antibiotic therapy induced a decrease in these parameters within approximately 30 min. If dicloran gel was injected after metrogil-dent, the maximum decrease in oxidative processes and antioxidant system activity was observed as soon as in 15 min.