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Merck

D7802

Daidzein

≥98% (TLC), powder, carbonic anhydrase (CA) inhibitor

Synonym(s):

4′,7-Dihydroxy­iso­flavone, 7-Hydroxy-3-(4-hydroxy­phenyl)-4H-1-benzo­pyran-4-one, 7-Hydroxy-3-(4-hydroxy­phenyl)­chromone, Isoaurostatin

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HUF 58,100.00

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HUF 169,000.00

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About This Item

Empirical Formula (Hill Notation):
C15H10O4
CAS Number:
486-66-8
Molecular Weight:
254.24
NACRES:
NA.77
PubChem Substance ID:
24278030
UNSPSC Code:
12352202
EC Number:
207-635-4
MDL number:
MFCD00016954
Beilstein/REAXYS Number:
231523

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Product Name

Daidzein, ≥98%, synthetic

InChI

1S/C15H10O4/c16-10-3-1-9(2-4-10)13-8-19-14-7-11(17)5-6-12(14)15(13)18/h1-8,16-17H

InChI key

ZQSIJRDFPHDXIC-UHFFFAOYSA-N

SMILES string

Oc1ccc(cc1)C2=COc3cc(O)ccc3C2=O

biological source

synthetic

assay

≥98%

form

powder

mp

>290 °C

solubility

DMSO: 10 mg/mL

storage temp.

−20°C

Quality Level

200

Gene Information

human ... ESR1(2099), ESR2(2100), UGT1A4(54657)
mouse ... Aldh1a2(19378), Hexa(15211), Maoa(17161)
rat ... Aldh1a2(116676)

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This Item
116242116587251600
Daidzein ≥98%, synthetic

Sigma-Aldrich

D7802

Daidzein

Daidzein United States Pharmacopeia (USP) Reference Standard

USP

1162421

Daidzein

Daidzein analytical standard

Supelco

16587

Daidzein

Daidzein Inactive analog of Genistein.

Sigma-Aldrich

251600

Daidzein

assay

≥98%

assay

-

assay

≥97.0% (HPLC)

assay

≥98% (TLC)

form

powder

form

-

form

-

form

solid

Quality Level

200

Quality Level

-

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

DMSO: 10 mg/mL

solubility

-

solubility

-

solubility

DMSO: 200 mg/mL

biological source

synthetic

biological source

-

biological source

-

biological source

-

Application

Daidzein has been used:
  • as a control to evaluate fertility in rats[1][2]
  • to study its effects on ovarian cancer[3]
  • to simulate in vitro antioxidant activity[4]

Biochem/physiol Actions

Daidzein is a phytoestrogen that is suggested to play a role in preventing hormone-induced cancers.[5] Arrests cell cycle at G1 in Swiss 3T3 cells.[6]
Soy isoflavone daidzein protects against oxidative damage in liver cells induced by 7,12-dimethylbenz[a]anthracene (DMBA). Catalase and superoxide dismutase activity, down-regulated by DMBA, was restored by daidzein.

General description

Daidzein is an isoflavone present in soy.[7] It regulates oxidative stress, angiogenesis, cell growth and apoptosis.[8] Daidzein has antioxidant, antiestrogenic and antiatherogenic properties. It provides protection against osteoporosis.[9]

Packaging

Packaged under Argon.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000486497
0000486516
0000486497
0000486516
0000421210

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Estrogen receptor modulators genistein, daidzein and ERB-041 inhibit cell migration, invasion, proliferation and sphere formation via modulation of FAK and PI3K/AKT signaling in ovarian cancer
Chan KKL, et al.
Cancer Cell International, 18(1), 65-65 (2018)
K Higashi et al.
Biochimica et biophysica acta, 1221(1), 29-35 (1994-03-10)
An isoflavone compound, daidzein, inhibits the cell proliferation of Swiss 3T3 cells. Analysis of entry in S phase of Swiss 3T3 cells reveals that daidzein blocked cell cycle G1 phase progression 4.6 h after stimulation by bombesin plus insulin. After
Conversion of daidzein and genistein by an anaerobic bacterium newly isolated from the mouse intestine
Matthies A, et al.
Applied and Environmental Microbiology, 74(15), 4847-4852 (2008)
Pharmacology E-Book: A Handbook for Complementary Healthcare Professionals (2008)
Epigenetic Cancer Therapy (2015)
View All Related Papers

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