196487

4-Biphenylacetic acid

Name: 4-Biphenylacetic acid
Brand: ALDRICH
Price: 44.55 EUR

98%

Slide 1 of 2

Autenticati per visualizzare i prezzi organizzativi e contrattuali.

Scegli un formato

5 G

44,55 €

Prezzo di listino59,40 €Risparmia il 25%

Per informazioni sulla disponibilità, contatta il Servizio Clienti.

Richiedi un ordine in blocco

Informazioni su questo articolo

Formula condensata:

C₆H₅C₆H₄CH₂CO₂H

Numero CAS:

5728-52-9

Peso molecolare:

212.24

NACRES:

NA.22

PubChem Substance ID:

24851763

UNSPSC Code:

12352100

EC Number:

227-233-2

MDL number:

MFCD00004351

Documenti fondamentali

Visualizza tutta la documentazione

Vai a

Servizio Tecnico

Hai bisogno di aiuto? Il nostro team di scienziati qualificati è a tua disposizione.

Permettici di aiutarti

Nome del prodotto

4-Biphenylacetic acid, 98%

InChI key

QRZAKQDHEVVFRX-UHFFFAOYSA-N

InChI

1S/C14H12O2/c15-14(16)10-11-6-8-13(9-7-11)12-4-2-1-3-5-12/h1-9H,10H2,(H,15,16)

SMILES string

OC(=O)Cc1ccc(cc1)-c2ccccc2

assay

98%

mp

159-160 °C (lit.)

solubility

DMSO: soluble 50 mg/mL, clear, colorless to yellow

Quality Level

100

Gene Information

human ... BAD(572)

Cerchi prodotti simili? Visita Guida al confronto tra prodotti

Categorie correlate

Chemical Building Blocks

Organic Building Blocks

Confronta articoli simili

Visualizza il confronto per intero

Mostra le differenze

1 of 4

Questo articolo	233021	77947	855057
Sigma-Aldrich 196487 4-Biphenylacetic acid	Sigma-Aldrich 233021 4-(Trifluoromethyl)phenylacetic acid	Supelco 77947 4-(2-Hydroxy-3-isopropylaminopropoxy)phenylacetic acid	Sigma-Aldrich 855057 Betulinic acid
assay 98%	assay 97%	assay ≥97.0% (HPLC)	assay 90%
solubility DMSO: soluble 50 mg/mL, clear, colorless to yellow	solubility -	solubility -	solubility -
Quality Level 100	Quality Level 200	Quality Level 100	Quality Level 100
mp 159-160 °C (lit.)	mp 82-85 °C (lit.)	mp -	mp 295-298 °C (dec.) (lit.)
Gene Information human ... BAD(572)	Gene Information -	Gene Information -	Gene Information -

Application

4-Biphenylacetic acid was used in the synthesis of gastrosparing non-steroidal antiinflammatory drug[1].

General description

4-Biphenylacetic acid is a potential non-steroidal antiinflammatory agent and forms solid inclusion complex with β-cyclodextrin[2]. 4-Biphenylacetic acid on interaction with quinolone antibacterial agents induces functional blockade of the γ-aminobutyric acid receptors[3].

pictograms

GHS06

signalword

Danger

hcodes

H301 + H331,H315,H319,H335

pcodes

P261 - P264 - P301 + P310 - P302 + P352 - P304 + P340 + P311 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Scegli una delle versioni più recenti:

Certificati d'analisi (COA)

Lot/Batch Number

Non trovi la versione di tuo interesse?

Se hai bisogno di una versione specifica, puoi cercare il certificato tramite il numero di lotto.

Cerca un COA

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

Enhancement of 4-biphenylacetic acid bioavailability in rats by its beta-cyclodextrin complex after oral administration.

G Puglisi et al.

The Journal of pharmacy and pharmacology, 43(6), 430-432 (1991-06-01)

4-Biphenylacetic acid, a potent non-steroidal anti-inflammatory agent forms a solid inclusion complex with beta-cyclodextrin in a 1:1 molar ratio, which exhibits better solubility and dissolution characteristics than the uncomplexed drug. Following oral administration of the complex to rats, quicker and

Possible intermolecular interaction between quinolones and biphenylacetic acid inhibits gamma-aminobutyric acid receptor sites.

K Akahane et al.

Antimicrobial agents and chemotherapy, 38(10), 2323-2329 (1994-10-01)

The combination of some new quinolone antibacterial agents with 4-biphenylacetic acid (BPAA), a metabolite of fenbufen, is known to specifically induce functional blockade of the gamma-aminobutyric acid (GABA) receptors. The mechanisms of these drug interactions were further examined. Scatchard analysis

Characterization of the interaction between a novel convulsant agent, norbiphen, and GABA(A) and other ligand-gated ion channels.

R F Halliwell et al.

Neuropharmacology, 43(4), 778-787 (2002-10-09)

A hybrid molecule composed of the antimicrobial, norfloxacin, linked to the non-steroidal anti-inflammatory drug (NSAID), biphenylacetic acid, which we have termed norbiphen, is a lethal convulsant in vivo and an antagonist of rodent GABA(A) receptors in vitro. In the present

Discovery of biphenylacetamide-derived inhibitors of BACE1 using de novo structure-based molecular design.

N Yi Mok et al.

Journal of medicinal chemistry, 56(5), 1843-1852 (2013-02-05)

β-Secretase (BACE1), the enzyme responsible for the first and rate-limiting step in the production of amyloid-β peptides, is an attractive target for the treatment of Alzheimer's disease. In this study, we report the application of the de novo fragment-based molecular

A novel protocol for the oral administration of test chemicals to adult zebrafish.

Liqing Zang et al.

Zebrafish, 8(4), 203-210 (2011-12-21)

A novel protocol using gluten as a carrier material was developed to administer chemicals to adult zebrafish, per os (p.o.). To evaluate the capacity of gluten to retain chemicals, we prepared gluten granules containing eight types of chemicals with different

Visualizza tutti i documenti correlati

Domande

Recensioni

Nessuna valutazione

Filtri attivi

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica