05-780

Anti-Akt3/PKBγ Antibody, clone GMA104

Name: Anti-Akt3/PKBγ Antibody, clone GMA104
Brand: MM

clone GMA104, Upstate^®, from mouse

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Informazioni su questo articolo

Codice UNSPSC:

12352203

eCl@ss:

32160702

NACRES:

NA.41

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Origine biologica

mouse

Livello qualitativo

100

Coniugato

unconjugated

Forma dell’anticorpo

purified antibody

Tipo di anticorpo

primary antibodies

Clone

GMA104, monoclonal

Reattività contro le specie

human

Produttore/marchio commerciale

Upstate^®

tecniche

immunoprecipitation (IP): suitable
western blot: suitable

Isotipo

IgG2a

N° accesso NCBI

NM_005465

N° accesso UniProt

Q9Y243

Condizioni di spedizione

wet ice

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... AKT3(10000)

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Questo articolo	07-383	05-796	04-1643
Sigma-Aldrich 05-780 Anti-Akt3/PKBγ Antibody, clone GMA104	Sigma-Aldrich 07-383 Anti-Akt3/PKBγ Antibody	Sigma-Aldrich 05-796 Anti-Akt1/PKBα Antibody, clone AW24, rabbit monoclonal	Sigma-Aldrich 04-1643 Rabbit Anti-Mouse IgG Antibody, clone RM104
species reactivity human	species reactivity human	species reactivity human, mouse, rat	species reactivity mouse
antibody form purified antibody	antibody form affinity purified immunoglobulin	antibody form purified antibody	antibody form purified antibody
clone GMA104, monoclonal	clone polyclonal	clone AW24, monoclonal	clone RM104, monoclonal
biological source mouse	biological source rabbit	biological source rabbit	biological source rabbit
shipped in wet ice	shipped in dry ice	shipped in dry ice	shipped in wet ice
technique(s) immunoprecipitation (IP): suitable, western blot: suitable	technique(s) immunoprecipitation (IP): suitable, western blot: suitable	technique(s) immunoprecipitation (IP): suitable, western blot: suitable	technique(s) ELISA: suitable, western blot: suitable

Descrizione generale

~60kDa

Immunogeno

peptide corresponding to amino acids 119-131 (CSPTSQIDNIGEE) of human Akt3/PKBγ

Applicazioni

Research Category
Signaling

Research Sub Category
PI3K, Akt, & mTOR Signaling

This Anti-Akt3/PKBγ Antibody, clone GMA104 is validated for use in IP, WB for the detection of Akt3/PKBγ.

Azioni biochim/fisiol

Predicted to cross-react with mouse and rat based on sequence homology.

RhoA

Stato fisico

Buffered solution containing 0.1M Tris-Glycine, 0.15M NaCl, 0.05% Sodium Azide, pH 7.4.

Format: Purified

Protein A purified

Nota sulla preparazione

Stable for 1 year at 2-8°C from date of receipt.

Risultati analitici

routinely evaluated by immunoblot on RIPA lysates from Jurkat or HL-60 cells

Note legali

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Certificati d'analisi (COA)

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K-Ras(V12) differentially affects the three Akt isoforms in lung and pancreatic carcinoma cells and upregulates E-cadherin and NCAM via Akt3.

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Characterization of PDK2 activity against protein kinase B gamma.

Conrad P Hodgkinson et al.

Biochemistry, 41(32), 10351-10359 (2002-08-07)

Protein kinase B (PKB), also known as Akt, is a serine/threonine protein kinase controlled by insulin, various growth factors, and phosphatidylinositol 3-kinase. Full activation of the PKB enzyme requires phosphorylation of a threonine in the activation loop and a serine

MicroRNA-497 impairs the growth of chemoresistant neuroblastoma cells by targeting cell cycle, survival and vascular permeability genes.

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Oncotarget, 7(8), 9271-9287 (2016-01-30)

Despite multimodal therapies, a high percentage of high-risk neuroblastoma (NB) become refractory to current treatments, most of which interfere with cell cycle and DNA synthesis or function, activating the DNA damage response (DDR). In cancer, this process is frequently altered

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