14-548-M

MSK1 Protein, active, 10 µg

Name: MSK1 Protein, active, 10 µg
Brand: MM
Price: 567 EUR
Availability: InStock

Active, N-terminal His6-tagged recombinant human MSK1 residues 2-end, for use in Kinase Assays.

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14-548

567,00 €

Spedizione prevista il05 gennaio 2026Dettagli

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Informazioni su questo articolo

Codice UNSPSC:

12352202

eCl@ss:

32160405

NACRES:

NA.32

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Origine biologica

human

Livello qualitativo

100

Ricombinante

expressed in baculovirus infected Sf21 cells

Nome Commerciale

Upstate^®

Attività specifica

(For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.)

PM

M_w 94 kDa

Purificato mediante

(Ni²⁺/NTA-agarose)

Reattività contro le specie

human

Produttore/marchio commerciale

Upstate^®

tecniche

activity assay: suitable (kinase)

Numero d’accesso

(FUNCTION: SwissProt: O75582 # Serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). Essential role in the control of RELA transcriptional activity in response to TNF. Directly represses transcription via phosphorylation of ′Ser-1′ of histone H2A. Phosphorylates ′Ser-10′ of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate ′Ser-28′ of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14). )
NM_004755.2

N° accesso NCBI

NM_004755.2
NM_182398.1

N° accesso UniProt

O75582

Malattie correlate

metabolic disorders; cardiovascular diseases

Informazioni sul gene

human ... RPS6KA5(9252)

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Questo articolo	14-616-M	14-624-M	14-452-M
Sigma-Aldrich 14-548-M MSK1 Protein, active, 10 µg	Sigma-Aldrich 14-616-M MSK2 Protein, active, 10 µg	Sigma-Aldrich 14-624-M MST1 Protein, active, 10 µg	Sigma-Aldrich 14-452-M PDK1 Protein, active, 10 µg
biological source human	biological source human	biological source human	biological source human
technique(s) activity assay: suitable (kinase)	technique(s) activity assay: suitable (kinase)	technique(s) activity assay: suitable (kinase)	technique(s) activity assay: suitable (kinase)
recombinant expressed in baculovirus infected Sf21 cells	recombinant expressed in baculovirus infected Sf21 cells	recombinant expressed in baculovirus infected Sf21 cells	recombinant expressed in baculovirus infected Sf21 cells
mol wt M_w 94 kDa	mol wt M_w 89.9 kDa	mol wt M_w 57 kDa	mol wt M_w 59 kDa
Gene Information human ... RPS6KA5(9252)	Gene Information human ... RPS6KA4(8986)	Gene Information human ... STK4(6789)	Gene Information human ... PDPK1(5170)
UniProt accession no. O75582	UniProt accession no. O75676	UniProt accession no. Q13043	UniProt accession no. O15530

Descrizione generale

MSK1

N-terminal His6-tagged recombinant human MSK1 residues 2-end

Applicazioni

Research Category
Metabolism

Research Sub Category
Cardiovascular Disease

Metabolic Disorders

Azioni biochim/fisiol

Protein Target: MSK1

Target Sub-Family: AGC

Confezionamento

Also available in 10 μg size and in bulk

Also available in 250 µg size --call for pricing and availability and reference catalog number 14-548M when ordering the 250 µg size.

Stato fisico

Ni²⁺/NTA-agarose

Nota sulla preparazione

6 months at -20°C

Risultati analitici

routinely evaluated by phosphorylation of Crosstide

Altre note

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Note legali

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Pittogrammi

GHS07

Avvertenze

Warning

Indicazioni di pericolo

H317

Consigli di prudenza

P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364

Classi di pericolo

Skin Sens. 1

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Reduction of protein kinase A-mediated phosphorylation of ATXN1-S776 in Purkinje cells delays onset of Ataxia in a SCA1 mouse model.

Judit M Pérez Ortiz et al.

Neurobiology of disease, 116, 93-105 (2018-05-15)

Spinocerebellar ataxia type 1 (SCA1) is a polyglutamine (polyQ) repeat neurodegenerative disease in which a primary site of pathogenesis are cerebellar Purkinje cells. In addition to polyQ expansion of ataxin-1 protein (ATXN1), phosphorylation of ATXN1 at the serine 776 residue

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