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Merck

324517

4EGI-1

≥98% (sum of two isomers, HPLC), eIF4E inhibitor, solid

Sinonimo/i:

eIF4E/eIF4G Interaction Inhibitor, 4EGI-1, 2-((4-(3,4-Dichlorophenyl)-thiazol-2-ylhydrazono)-3-(2-nitrophenyl))propionic acid, eIF4F Inhibitor I

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10 MG

245,00 €

245,00 €

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Informazioni su questo articolo

Formula empirica (notazione di Hill):
C18H12Cl2N4O4S
Numero CAS:
315706-13-9
Peso molecolare:
451.28
Numero MDL:
MFCD10565943
Codice UNSPSC:
12352200
NACRES:
NA.77

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Nome del prodotto

eIF4E/eIF4G Interaction Inhibitor, 4EGI-1, The eIF4E/eIF4G Interaction Inhibitor, 4EGI-1, also referenced under CAS 315706-13-9, controls the biological activity of eIF4E/eIF4G interaction. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Livello qualitativo

100

Saggio

≥98% (sum of two isomers, HPLC)

Stato

solid

Produttore/marchio commerciale

Calbiochem®

Condizioni di stoccaggio

OK to freeze
protect from light

Colore

yellow

Solubilità

DMSO: 100 mg/mL

Condizioni di spedizione

ambient

Temperatura di conservazione

2-8°C

InChI

1S/C18H12Cl2N4O4S/c19-12-6-5-10(7-13(12)20)15-9-29-18(21-15)23-22-14(17(25)26)8-11-3-1-2-4-16(11)24(27)28/h1-7,9H,8H2,(H,21,23)(H,25,26)/b22-14+
KFRKRECSIYXARE-HYARGMPZSA-N

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Questo articolo
324519217505475956
eIF4E/eIF4G Interaction Inhibitor, 4EGI-1 The eIF4E/eIF4G Interaction Inhibitor, 4EGI-1, also referenced under CAS 315706-13-9, controls the biological activity of eIF4E/eIF4G interaction. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

324517

eIF4E/eIF4G Interaction Inhibitor, 4EGI-1

eIF4E/eIF4G Interaction Inhibitor, 4EGI-1 InSolution, ≥95%, reversibly binds eukaryotic translation initiation factor 4E

Sigma-Aldrich

324519

eIF4E/eIF4G Interaction Inhibitor, 4EGI-1

CBP-CREB Interaction Inhibitor The CBP-CREB Interaction Inhibitor, also referenced under CAS 92-78-4, controls the biological activity of CBP-CREB.

Sigma-Aldrich

217505

CBP-CREB Interaction Inhibitor

c-Myc Inhibitor The c-Myc Inhibitor, also referenced under CAS 403811-55-2, controls the biological activity of c-Myc.

Sigma-Aldrich

475956

c-Myc Inhibitor

form

solid

form

liquid

form

solid

form

solid

assay

≥98% (sum of two isomers, HPLC)

assay

≥95% (sum of two isomers, HPLC)

assay

≥97% (HPLC)

assay

≥95% (sum of two isomers, HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage temp.

2-8°C

storage temp.

−70°C

storage temp.

2-8°C

storage temp.

2-8°C

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, avoid repeated freeze/thaw cycles, desiccated (hygroscopic), protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

Descrizione generale

A cell-permeable hydrazone compound that reversibly binds eukaryotic translation initiation factor 4E (eIF4E; KD = 25 µM) and disrupts eIF4E/eIF4G, but not eIF4E/4E-BP1, complex formation. Reported to downregulate the protein, but not mRNA, levels of c-Myc and Bcl-xL in Jurkat cells (8 h), leading to apoptotic cell death after prolonged exposure (24 h, IC50 = ~ 25 µM). Also available as a 25 mM solution in DMSO (Cat. No. 324519).

Confezionamento

Packaged under inert gas

Nota sulla preparazione

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Altre note

Moerke, N. J., et al. 2007. Cell128, 257.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Esclusione di responsabilità

Toxicity: Harmful (C)

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

677.1 °F - (calculated)

Punto d’infiammabilità (°C)

358.4 °C - (calculated)

Certificati d'analisi (COA)

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