676377

Valinomycin, Streptomyces fulvissimus

A cyclododecadepsi-peptide ionophore antibiotic.

• Sinonimo/i: Valinomycin, Streptomyces fulvissimus
• Formula empirica (notazione di Hill): C₅₄H₉₀N₆O₁₈
• Numero CAS: 2001-95-8
• Peso molecolare: 1111.32
• Numero MDL: MFCD00005114
• Codice UNSPSC: 12352200

Proprietà

• Livello qualitativo: 200
• Saggio: ≥93% (HPLC)
• Stato: crystalline solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze
• Colore: white
• Solubilità: DMSO: soluble; acetic acid: soluble; chloroform: soluble; ether: soluble
• Condizioni di spedizione: ambient
• Temperatura di conservazione: 10-30°C
• InChI: 1S/C54H90N6O18/c1-22(2)34-49(67)73-31(19)43(61)55-38(26(9)10)53(71)77-41(29(15)16)47(65)59-36(24(5)6)51(69)75-33(21)45(63)57-39(27(11)12)54(72)78-42(30(17)18)48(66)60-35(23(3)4)50(68)74-32(20)44(62)56-37(25(7)8)52(70)76-40(28(13)14)46(64)58-34/h22-42H,1-21H3,(H,55,61)(H,56,62)(H,57,63)(H,58,64)(H,59,65)(H,60,66)/t31-,32-,33-,34+,35+,36?,37-,38-,39-,40+,41+,42+/m0/s1; FCFNRCROJUBPLU-UYBNATROSA-N

Descrizione

Descrizione generale

A cyclododecadepsi-peptide ionophore antibiotic. Potassium ionophore that transports alkali metal ions across artificial or biological lipid membranes (Rb⁺ >K⁺ >Cs⁺ >Ag⁺ >NH₄⁺ >Na⁺ >Li⁺). Induces K⁺ conductivity in cell membranes at concentrations as low as 10 nM. Because of its ability to affect membrane transport of K⁺ and to create a hydrophobic layer on solid electrodes, it is often used in membrane electrode systems for determining K⁺ concentration. Useful in studies of K⁺ transport in mitochondria. Uncouples oxidative phosphorylation by binding to sites on membranes rich in sulfhydryl groups. Induces apoptosis in murine thymocytes. Also reported to inhibit NGF-induced neuronal differentiation.

Azioni biochim/fisiol

Cell permeable: no

Primary Target
NGF-induced neuronal differentiation

Product does not compete with ATP.

Reversible: no

Altre note

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Harada, H., et al. 1994. Biochim. Biophys. Acta1220, 310.
Luvisetto, S., et al. 1994. Biochim. Biophys. Acta 1186, 12.
Orlov, V.N., et al. 1994. FEBS Lett.345, 104.
Acra, S., et al. 1993. Am. J. Physiol.264, G45.
Cornet, M., et al. 1993. J. Membr. Biol.131, 55.
Deckers, C.L., et al. 1993. Exp. Cell Res.208, 362.
Dimroth, P., and Thomer, A. 1993. Biochemistry32, 1734.
Opanasenko, V.K., et al. 1992. FEBS Lett.307, 280.
Pape, P.C., et al. 1992. J. Physiol.449, 219.
Ahmed, S., and Booth, I.R. 1983. Biochem. J.212, 105.
Lerner, A., et al. 1982. FEBS Lett.146, 9.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Esclusione di responsabilità

Toxicity: Highly Toxic (H)

Informazioni sulla sicurezza

• Pittogrammi: GHS06
• Avvertenze: Danger
• Indicazioni di pericolo: H300 + H310
• Consigli di prudenza: P262 - P264 - P280 - P301 + P310 - P302 + P352 + P310 - P361 + P364
• Classi di pericolo: Acute Tox. 1 Dermal - Acute Tox. 1 Oral
• Codice della classe di stoccaggio: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable