AB5384

Anti-Nitric Oxide Synthase II Antibody

Name: Anti-Nitric Oxide Synthase II Antibody
Brand: MM
Price: 424 EUR
Availability: InStock

serum, Chemicon^®

Sinonimo/i:

NOS II, iNOS

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50 μL

424,00 €

Spedizione prevista il02 febbraio 2026Dettagli

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Informazioni su questo articolo

Codice UNSPSC:

12352203

eCl@ss:

32160702

NACRES:

NA.41

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Origine biologica

rabbit

Livello qualitativo

100

Coniugato

unconjugated

Forma dell’anticorpo

serum

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Reattività contro le specie

human

Produttore/marchio commerciale

Chemicon^®

tecniche

immunohistochemistry: suitable
western blot: suitable

N° accesso NCBI

NM_000625.3
NM_153292.1

N° accesso UniProt

P35228

Condizioni di spedizione

dry ice

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... NOS2(4843)

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Questo articolo	N7782	SAB5700636	SAB4200766
Sigma-Aldrich AB5384 Anti-Nitric Oxide Synthase II Antibody	$Anti-Nitric Oxide Synthase, Inducible antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution$ Sigma-Aldrich N7782 Anti-Nitric Oxide Synthase, Inducible antibody produced in rabbit	Sigma-Aldrich SAB5700636 Anti-iNOS antibody produced in rabbit	Sigma-Aldrich SAB4200766 Anti-Nitric Oxide Synthase, Inducible antibody, Mouse monoclonal
antibody form serum	antibody form IgG fraction of antiserum	antibody form affinity isolated antibody	antibody form purified from hybridoma cell culture
biological source rabbit	biological source rabbit	biological source rabbit	biological source mouse
Quality Level 100	Quality Level 200	Quality Level 100	Quality Level 200
clone polyclonal	clone polyclonal	clone polyclonal	clone NOS-IN, monoclonal
technique(s) immunohistochemistry: suitable, western blot: suitable	technique(s) microarray: suitable, western blot: 1:10,000 using cells extract of murine RAW 264.7 macrophages activated with LPS and IFN-γ.	technique(s) western blot: 1:500-1:2000	technique(s) flow cytometry: suitable, immunoblotting: 2-4 μg/mL using mouse macrophage RAW 264.7 cell line activated with lipopolysaccharide (LPS) and interferon-γ, immunohistochemistry: 10-20 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded human pancreas sections
UniProt accession no. P35228	UniProt accession no. P29477	UniProt accession no. P35228	UniProt accession no. P35228

Descrizione generale

The inducible isoform of the enzyme nitric oxide synthase (iNOS, NOS-II) is synthesized by macrophages and many other cell types in response to proinflammatory cytokines and certain other stimuli, such as hypoxia and stress.

Immunogeno

C-terminal 19 amino acid peptide from human chondrocyte nitric oxide synthase.

Applicazioni

Detect Nitric Oxide Synthase II using this Anti-Nitric Oxide Synthase II Antibody validated for use in WB, IH.

Research Category
Neuroscience

Research Sub Category
Oxidative Stress

Western blot: 1:1,000-1:2,500 (ECL).

Immunohistochemistry: 1:2,500-1:6,000 (ABC).

Optimal working dilutions must be determined by end user.

Azioni biochim/fisiol

Inducible nitric oxide synthase (iNOS, NOS-II). No cross-reaction with nNOS and eNOS by immunohistochemistry. AB5384 reacts with human glia and certain neurons in Alzheimer′s disease by immunohistochemistry.

Stato fisico

Rabbit serum. Liquid containing 0.05% sodium azide.

Nota sulla preparazione

Maintain frozen at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.

Note legali

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

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Contenuto correlato

White Paper- Modern Methods in Oxidative Stress Research

"Redox reactions are powerful chemical processes that involve the reduction and oxidation of proteins and metabolites found in living things. The mechanisms that regulate them are key to maintaining homeostasis and the balance between good health and disease pathology. Oxidative stress is the state where the delicate balance of redox biology is upset, and the pathology of oxidative stress are the cellular consequences to such an imbalance."

RABBIT ANTI-INDUCIBLE NITRIC OXIDE SYNTHASE (iNOS)

Pathways and Biomarkers of Oxidative Stress

"Aging: getting older, exhibiting the signs of age, the decline in the physical (and mental) well-being over time, leading to death. Since the beginning of time, man has been obsessed with trying to slow down, stop, or even reverse the signs of aging. Many have gone as far as experimenting with nutritional regimens, eccentric exercises, fantastic rituals, and naturally occurring or synthetic wonder-elements to evade the signs of normal aging. Biologically speaking, what is aging? And what does the latest research tell us about the possibility of discovering the elusive “fountain of youth”? Many advances in our understanding of aging have come from systematic scientific research, and perhaps it holds the key to immortality. Scientifically, aging can be defined as a systems-wide decline in organismal function that occurs over time. This decline occurs as a result of numerous events in the organism, and these events can be classified into nine “hallmarks” of aging, as proposed by López-Otin et al. (2013). Several of the pathologies associated with aging are a direct result of these events going to extremes and may also involve aberrant activation of proliferation signals or hyperactivity. The hallmarks of aging have been defined based on their fulfillment of specific aging related criteria, such as manifestation during normal aging, acceleration of aging if experimentally induced or aggravated, and retardation of aging if prevented or blocked, resulting in increased lifespan. The nine hallmarks of aging are genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. The biological processes underlying aging are complex. By understanding the hallmarks in greater detail, we can get closer to developing intervention strategies that can make the aging process less of a decline, and more of a recline."

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