AB5883

Anti-Synapsin I Antibody, phosphoSer 603

Name: Anti-Synapsin I Antibody, phosphoSer 603
Brand: MM
Price: 398 EUR
Availability: InStock

Chemicon^®, from rabbit

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100 μL

398,00 €

Spedizione prevista il27 gennaio 2026Dettagli

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Informazioni su questo articolo

Codice UNSPSC:

12352203

eCl@ss:

32160702

NACRES:

NA.41

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Origine biologica

rabbit

Livello qualitativo

100

Forma dell’anticorpo

affinity purified immunoglobulin

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Purificato mediante

affinity chromatography

Reattività contro le specie

rat

Produttore/marchio commerciale

Chemicon^®

tecniche

western blot: suitable

N° accesso NCBI

NM_006950.3
NM_133499.2

N° accesso UniProt

P17600

Condizioni di spedizione

dry ice

modifica post-traduzionali bersaglio

phosphorylation (pSer603)

Informazioni sul gene

human ... SYN1(6853)

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Questo articolo	AB9848	SAB4504214	S8192
Sigma-Aldrich AB5883 Anti-Synapsin I Antibody, phosphoSer 603	Sigma-Aldrich AB9848 Anti-phospho-Synapsin I (Ser62,Ser67) Antibody	Sigma-Aldrich SAB4504214 Anti-phospho-Synapsin1 (pSer⁶⁰⁵) antibody produced in rabbit	Sigma-Aldrich S8192 Anti-phospho-Synapsin I (pSer⁶⁰³) antibody produced in rabbit
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
antibody form affinity purified immunoglobulin	antibody form affinity purified immunoglobulin	antibody form affinity isolated antibody	antibody form affinity isolated antibody
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 200
clone polyclonal	clone polyclonal	clone polyclonal	clone polyclonal
UniProt accession no. P17600	UniProt accession no. P17600	UniProt accession no. P17600	UniProt accession no. P17600
Gene Information human ... SYN1(6853)	Gene Information human ... SYN1(6853)	Gene Information human ... SYN1(6853)	Gene Information human ... SYN1(6853) mouse ... Syn1(20964) rat ... Syn1(24949)

Immunogeno

Epitope: phosphoSer 603

Synthetic peptide corresponding to amino acids surrounding the phosphoSer603 of rat Synapsin I. The immunogen sequence is identical in human, mouse and Xenopus.

Applicazioni

Anti-Synapsin I Antibody, phosphoSer 603 detects level of Synapsin I & has been published & validated for use in WB.

Research Category
Neuroscience

Research Sub Category
Synapse & Synaptic Biology

Western blot: 1:1,000. Rat brain lysate shows a ~78-80kDa band.

Optimal working dilutions must be determined by the end user.

Azioni biochim/fisiol

Synapsin I, phosphoSer603. This is the site phosphorylated by Calcium calmodulin kinase II. The antibody recognizes the ~78 kD Synapsin I, phosphoSer603 protein. Immunolabeling is blocked by the immunogen peptide but no by the corresponding non-phospho peptide.

Stato fisico

Affinity purified immunoglobulin presented as a liquid in 10 mM HEPES, pH 7.5, with 150 mM NaCl, 100 μg/mL BSA and 50% glycerol.

Nota sulla preparazione

Maintain at -20°C in undiluted for up to 6 months from date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self-defrosting freezer.

Note legali

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Certificati d'analisi (COA)

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Synaptic protein changes after a chronic period of sensorimotor perturbation in adult rats: a potential role of phosphorylation/O-GlcNAcylation interplay.

Julie Fourneau et al.

Journal of neurochemistry, 147(2), 240-255 (2018-05-29)

In human, a chronic sensorimotor perturbation (SMP) through prolonged body immobilization alters motor task performance through a combination of peripheral and central factors. Studies performed on a rat model of SMP have shown biomolecular changes and a reorganization of sensorimotor

Contenuto correlato

Pathways and Biomarkers of Glutamatergic Synapse Flyer

Glutamate is an excitatory neurotransmitter found in the synaptic vesicles of glutamatergic synapses. The post-synaptic neurons in these synapses contain ionotropic and metabotropic glutamate receptors. Glutamate binds to AMPA (α-amino-3-hydroxy-5- methylisoxazole-4-propionic acid) subtype glutamate receptors, leading to sodium influx into the post-synaptic cell and resulting in neuronal excitability and synaptic transmission. The NMDA (N-methyl-d-aspartate) subtype glutamate receptors, on the other hand, regulate synaptic plasticity, and can influence learning and memory. The metabotropic g-protein coupled mGluRs modulate downstream calcium signaling pathways and indirectly influence the synapse’s excitability. The synaptic architecture includes intracellular scaffolding proteins (PSD-95, GRIP), intercellular cell adhesion molecules (NCAMs, N-Cadherins), and a variety of signaling proteins (CaMKII/PKA, PP1/PP2B). Processes critical for synaptic transmission and plasticity are influenced by these molecules and their interactions. When the function of these molecules is disrupted, it leads to synaptic dysfunction and degeneration, and can contribute to dementia as seen in Alzheimer’s disease.

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