MABN832
Anti-pan-AMPA receptor (GluR1-4), clone 2D8 Antibody
clone 2D8, from mouse
Sinonimo/i:
Glutamate receptor 1, GluR-1, AMPA-selective glutamate receptor 1, GluR-A, GluR-K1, Glutamate receptor ionotropic, AMPA 1, GluA1
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100 μG
443,00 €
443,00 €
Spedizione prevista per OGGIDettagli
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Informazioni su questo articolo
Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
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Servizio Tecnico
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Permettici di aiutartiOrigine biologica
mouse
Livello qualitativo
Coniugato
unconjugated
Forma dell’anticorpo
purified antibody
Tipo di anticorpo
primary antibodies
Clone
2D8, monoclonal
Reattività contro le specie
human, rat
tecniche
ELISA: suitable
electron microscopy: suitable
immunocytochemistry: suitable
immunofluorescence: suitable
immunohistochemistry: suitable
western blot: suitable
Isotipo
IgG2bκ
Condizioni di spedizione
wet ice
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... GRIA1(2890)
1 of 4
Questo articolo | MABN71 | ABN241 | MAB397A4 |
|---|---|---|---|
| species reactivity human, rat | species reactivity rat | species reactivity human, mouse, rat | species reactivity mouse, rat |
| biological source mouse | biological source mouse | biological source rabbit | biological source mouse |
| Gene Information human ... GRIA1(2890) | Gene Information human ... GRIA2(2891) | Gene Information human ... GRIA1(2890) | Gene Information human ... GRIA2(2891) |
| clone 2D8, monoclonal | clone L21/32, monoclonal | clone polyclonal | clone 6C4, monoclonal |
| antibody form purified antibody | antibody form purified antibody | antibody form affinity isolated antibody | antibody form purified immunoglobulin |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. |
Descrizione generale
Glutamate receptors are synaptic receptors located primarily on the membranes of neuronal cells. Upon ligand stimulation, ionotropic glutamate receptors (iGluRs) form non-selective cation channels, while metabotropic glutamate receptors (mGluRs) indirectly activate ion channels via G protein-mediated signaling. AMPA receptors are iGluRs and are also known as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors, AMPARs, or quisqualate receptors. AMPARs are composed of four types of subunits, GluR1/GluA1 (UniProt P42261) is encoded by GRIA1, GluR2/GluA2 (UniProt P42262) by GRIA2, GluR3/GluA3 (UniProt P42263) by GRIA3, and GluR4/GluA4 (UniProt P48058) by GRIA4 gene in human. AMPARs are tetrameric in nature, consisting of two sets of homodimers, most often a set of GluR2 dimer is coupled with a set of GluR1, GluR3 or GluR4 homodimer. Cat. No. Anti-pan-AMPA receptor (GluR1-4), clone 2D8, reacts with all four AMPA receptor subunits.
~85 kDa observed. Uncharacterized band(s) may appear in some lysates.
Immunogeno
Fusion protein coding for the extracellular domain of AMPA Glutamate receptor 1-4 corresponding to human pan-AMPA receptor (GluR1-4).
Applicazioni
Anti-pan-AMPA receptor (GluR1-4), clone 2D8 Antibody is an antibody against AMPA receptor for use in Western Blotting, Immunohistochemistry and Immunocytochemistry, Enzyme Immunoassay (ELISA), Electron Microscopy and Immunofluorescence.
Western Blotting Analysis: 0.5 µg/mL from a representative lot detected AMPA receptor (GluR1-4) in 10 µg of human brain tissue lysate.
Western Blotting Analysis: 1.0 µg/mL from a representative lot detected AMPA receptor (GluR1-4) in 10 µg of transfected human GluA1 HEK293, transfected rat GluA1 HEK293, transfected rat GluA2 HEK293, transfected rat GluA3 HEK293, and Mock transfected cell lysate.
Immunohistochemistry Analysis: A 1:250-1,000 dilution from a representative lot detected AMPA receptor (GluR1-4) in human cerebral cortex, human thalamus, rat cerebellum, and rat cerebral cortex tissue.
Immunocytochemistry Analysis: A representative lot detected AMPA receptor (GluR1-4) in Hela cells transfected with GluA1, GluA2, GluA3 and GluA4 (Courtesy of Dr John Morrison, Mount Sinai School of Medicine).
Immunofluorescence Analysis: A representative lot detected AMPA receptor (GluR1-4) in rodent, primate and human brain sections (Courtesy of Dr John Morrison, Mount Sinai School of Medicine).
Electron Microscopy Analysis: A representative lot detected AMPA receptor (GluR1-4) in rat hippocampus (Courtesy of Dr John Morrison, Mount Sinai School of Medicine).
ELISA Analysis: A representative lot detected AMPA receptor (GluR1-4) in TrpE fusion proteins (Courtesy of Dr John Morrison, Mount Sinai School of Medicine).
Western Blotting Analysis: 1.0 µg/mL from a representative lot detected AMPA receptor (GluR1-4) in 10 µg of transfected human GluA1 HEK293, transfected rat GluA1 HEK293, transfected rat GluA2 HEK293, transfected rat GluA3 HEK293, and Mock transfected cell lysate.
Immunohistochemistry Analysis: A 1:250-1,000 dilution from a representative lot detected AMPA receptor (GluR1-4) in human cerebral cortex, human thalamus, rat cerebellum, and rat cerebral cortex tissue.
Immunocytochemistry Analysis: A representative lot detected AMPA receptor (GluR1-4) in Hela cells transfected with GluA1, GluA2, GluA3 and GluA4 (Courtesy of Dr John Morrison, Mount Sinai School of Medicine).
Immunofluorescence Analysis: A representative lot detected AMPA receptor (GluR1-4) in rodent, primate and human brain sections (Courtesy of Dr John Morrison, Mount Sinai School of Medicine).
Electron Microscopy Analysis: A representative lot detected AMPA receptor (GluR1-4) in rat hippocampus (Courtesy of Dr John Morrison, Mount Sinai School of Medicine).
ELISA Analysis: A representative lot detected AMPA receptor (GluR1-4) in TrpE fusion proteins (Courtesy of Dr John Morrison, Mount Sinai School of Medicine).
Stato fisico
Format: Purified
Risultati analitici
Evaluated by Western Blotting in rat brain tissue lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected AMPA receptor (GluR1-4) in 10 µg of rat brain tissue lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected AMPA receptor (GluR1-4) in 10 µg of rat brain tissue lysate.
Altre note
Concentration: Please refer to lot specific datasheet.
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Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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