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Merck

17772

Retinolo

≥95.0% (HPLC), ~2700 U/mg

Sinonimo/i:

tutto trans-3,7-dimetil-9-(2,6,6-trimetil-1-cicloesen-1-il)-2,4,6,8-nonatetraen-1-olo, Alcol della vitamina A, Axeroftolo, Vitamina A, Vitamina A1

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Informazioni su questo articolo

Formula empirica (notazione di Hill):
C20H30O
Numero CAS:
68-26-8
Peso molecolare:
286.45
Beilstein:
403040
Numero CE:
200-683-7
Numero MDL:
MFCD00001552
Codice UNSPSC:
12352205
eCl@ss:
34058018
ID PubChem:
329751561
NACRES:
NA.79

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Origine biologica

synthetic

Saggio

≥95.0% (HPLC)

Stato

(Powder or Crystal with Lumps)

Attività specifica

~2700 U/mg

Colore

yellow to dark yellow

Punto di fusione

61-63 °C (lit.)

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

Stringa SMILE

CC1(C)C(/C=C/C(C)=C/C=C/C(C)=C/CO)=C(C)CCC1

InChI

1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
FPIPGXGPPPQFEQ-OVSJKPMPSA-N

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1 of 4

Questo articolo
95144R763287809
Retinolo ≥95.0% (HPLC), ~2700 U/mg

Sigma-Aldrich

17772

Retinolo

Retinolo BioXtra, ≥97.5% (HPLC), ~3100 U/mg

Sigma-Aldrich

95144

Retinolo

Retinolo synthetic, ≥95% (HPLC), (Powder or Powder with Lumps)

Sigma-Aldrich

R7632

Retinolo

Retinyl propionate ≥98.0% (sum of isomers, HPLC), ~2500 U/mg

Sigma-Aldrich

87809

Retinyl propionate

assay

≥95.0% (HPLC)

assay

≥97.5% (HPLC)

assay

≥95% (HPLC)

assay

≥98.0% (sum of isomers, HPLC)

biological source

synthetic

biological source

synthetic

biological source

synthetic

biological source

synthetic

form

(Powder or Crystal with Lumps)

form

(Powder or Powder with Lumps)

form

(Powder or Powder with Lumps)

form

liquid

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

color

yellow to dark yellow

color

faint yellow to very dark yellow

color

yellow to very dark yellow, to Very Dark Orange

color

green-yellow to very dark green-yellow, yellow to very dark yellow

mp

61-63 °C (lit.)

mp

56-61 °C, 61-63 °C (lit.)

mp

61-63 °C (lit.)

mp

-

Descrizione generale

Retinal, retinol and retinoic acid are the aldehyde, alcohol and acid forms of vitamin A. The retinoids exist as many geometric isomers due to the unsaturated bonds in the aliphatic chain. Retinol is biologically active in a wide range of processes.
Retinol or all-trans-retinol is a 20-carbon molecule with cyclohexenyl ring, a side chain with four double bonds (all in trans configuration) and an alcohol end group.[1]

Applicazioni

Retinol has been used as a standard in ultra-performance liquid chromatography - tandem mass spectrometer (UPLC-MS/MS) for the vitamins detection and quantification.[2]

Azioni biochim/fisiol

Retinol and its derivatives exhibit anti-aging properties. Retinol is used for treating wrinkles and signs of aging. However, due to its photo instability and skin irritation potency, it is hardly used in cosmetic formulations.[2] Retinol is also used as a therapeutic for dermatoses. Its deficiency leads to xerosis and follicular hyperkeratosis.[1]

Altre note

1 U corresponds to 1 international U acc. to Ph Eur II, 217 (1983)

Pittogrammi

Health hazardExclamation mark
GHS08,GHS07

Avvertenze

Danger

Indicazioni di pericolo

H317,H319,H360FD,H413

Classi di pericolo

Aquatic Chronic 4 - Eye Irrit. 2 - Repr. 1B - Skin Sens. 1

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 1

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
BCCM9151
BCCL0766
BCCL4157
BCCH8320
BCCH0024

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Effects of dietary lead exposure on vitamin levels in great tit nestlings-An experimental manipulation
Ruiz S, et al.
Environmental Pollution (Barking, Essex : 1987), 213(2), 688-697 (2016)
N M Hamdan et al.
Journal of dental research, 92(12 Suppl), 146S-153S (2013-10-26)
People wearing mandibular two-implant overdentures (IOD) chew food with less difficulty than those wearing conventional complete dentures (CD). However, there is still controversy over whether or not this results in better dietary intake. In this randomized clinical trials (RCT), the
Grace M Egeland et al.
Canadian journal of public health = Revue canadienne de sante publique, 95(6), 465-469 (2004-12-30)
Inuit traditional food provides ample amounts of preformed vitamin A. However, the dietary transition away from traditional food raises concerns regarding dietary adequacy. Vitamin A is an essential nutrient with inadequate and excessive exposures having adverse effects. To evaluate total
Frank T Wieringa et al.
The American journal of clinical nutrition, 77(3), 651-657 (2003-02-26)
Deficiencies of iron and vitamin A are prevalent worldwide. Single-micronutrient supplementation is widely used to combat these deficiencies. However, micronutrient deficiencies often occur concurrently, and there are many interactions between micronutrients. This study investigated interactions among 3 important micronutrients--iron, vitamin
Karen M Edmond et al.
Lancet (London, England), 385(9975), 1315-1323 (2014-12-17)
Results of randomised controlled trials of newborn (age 1-3 days) vitamin A supplementation have been inconclusive. The WHO is coordinating three large randomised trials in Ghana, India, and Tanzania (Neovita trials). We present the findings of the Neovita trial in
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Domande

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  1. How can I determine the shelf life / expiration / retest date of this product?

    1 risposta

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 risposta

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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