A7910
Apolipoprotein C-II from human plasma
≥95% (SDS-PAGE)
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Permettici di aiutartiOrigine biologica
human
Livello qualitativo
Saggio
≥95% (SDS-PAGE)
Stato
powder
PM
average mol wt 8.8 kDa
tecniche
ligand binding assay: suitable
N° accesso UniProt
Temperatura di conservazione
−20°C
Informazioni sul gene
human ... APOC2(344)
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Questo articolo | RAB0612 | A7785 | A0972 |
|---|---|---|---|
| technique(s) ligand binding assay: suitable | technique(s) ELISA: suitable | technique(s) inhibition assay: suitable | technique(s) - |
| biological source human | biological source - | biological source human | biological source human plasma |
| assay ≥95% (SDS-PAGE) | assay - | assay ≥95% (SDS-PAGE) | assay ≥95% (SDS-PAGE) |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| form powder | form - | form lyophilized powder | form buffered aqueous solution |
| Quality Level 200 | Quality Level - | Quality Level 200 | Quality Level 200 |
Descrizione generale
Apolipoprotein C-II (APOC2/apoC-II), a small exchangeable apolipoprotein, is expressed in the liver and secreted into plasma. It is present on the triglyceride-rich lipoproteins (TRL), like chylomicrons (CM) and very-low-density lipoproteins (VLDL), and high-density lipoproteins (HDL), mainly during fasting. The intestine, macrophages, adipose tissue, brain, skin, lungs, retina, and retinal pigment epithelium are among the tissues that produce ApoC-II.[1]
Applicazioni
Apolipoprotein C-II activates lipoprotein lipase and has been used in a study to assess HDL proteome in hemodialysis patients. An excess of apolipoprotein C-II is associated with increased triglyceride-rich particles and alterations in HDL particle distribution.
Azioni biochim/fisiol
Activates lipoprotein lipase
Apolipoprotein C2 (APOC2) serves as an activator of lipoprotein lipase. It is involved in the hydrolysis of triglycerides (TG) on TG-rich lipoproteins (TRL)[1] to release free fatty acids (FA).[2] Higher expression of APOC2 is observed in patient-derived glioblastoma stem cells, hypopharyngeal cancer, invasive ductal breast cancer, clear cell renal cell carcinoma, gastric cancer, centroblastic lymphoma, early-stage colorectal tumor, and skin squamous cell carcinoma.[2] ApoC-2 is considered as a new sensitive biomarker for diagnosing Takayasu arteritis (TAK).[3]
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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Natsuko Tamura et al.
Scientific reports, 11(1), 18958-18958 (2021-09-25)
Takayasu arteritis (TAK) is an autoimmune systemic arteritis of unknown etiology. Although a number of investigators have attempted to determine biomarkers for diagnosing TAK, there exist no specific serological markers of this intractable disease. We undertook the exploration of novel
Alain Mangé et al.
PloS one, 7(3), e34107-e34107 (2012-04-04)
Aside from a decrease in the high-density lipoprotein (HDL) cholesterol levels, qualitative abnormalities of HDL can contribute to an increase in cardiovascular (CV) risk in end-stage renal disease (ESRD) patients undergoing chronic hemodialysis (HD). Dysfunctional HDL leads to an alteration
Anna Wolska et al.
Atherosclerosis, 267, 49-60 (2017-11-04)
Apolipoprotein C-II (apoC-II) is a small exchangeable apolipoprotein found on triglyceride-rich lipoproteins (TRL), such as chylomicrons (CM) and very low-density lipoproteins (VLDL), and on high-density lipoproteins (HDL), particularly during fasting. ApoC-II plays a critical role in TRL metabolism by acting
Deregulation of apolipoprotein C2 gene in cancer: A potential metabolic vulnerability.
Yuqiao Liu et al.
Clinical and translational medicine, 11(6), e406-e406 (2021-06-30)
Vishnu Swarup et al.
Neuroscience research, 73(2), 161-167 (2012-03-20)
Spinocerebellar ataxia 12 (SCA12) is a unique dominant type of ataxia characterized by early and prominent action tremors, memory deficit, neuropathy, dysarthria, etc. The expansion of DNA triplet (CAG) repeats in 5'UTR of PPP2R2B gene appears to be the cause
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