C1288
Complement C6 deficient serum human
for complement assays
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Informazioni su questo articolo
Codice UNSPSC:
12352202
NACRES:
NA.61
Vai a
Servizio Tecnico
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Questo articolo | C0913 | C1163 | C2910 |
|---|---|---|---|
| technique(s) activity assay: suitable | technique(s) activity assay: suitable | technique(s) activity assay: suitable | technique(s) activity assay: suitable |
| biological source human | biological source human | biological source human | biological source human |
| form liquid | form liquid | form solution | form solution |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. |
| storage temp. −70°C | storage temp. −70°C | storage temp. −70°C | storage temp. −70°C |
| shipped in dry ice | shipped in dry ice | shipped in - | shipped in dry ice |
Applicazioni
Complement C6 is one of the end terminals of the complement system contained in the membrane attack complex (MAC). A deficiency of C6 may result in an increased susceptibility to Neisseria meningitidis. Research has identified that a mutation which leads to a 31 bp deletion in exon 10 in the C6 gene results in C6 deficiency. A coagulation defect has also been observed in mice that are C6 deficient.
Stato fisico
Supplied as a solution in PBS, pH 7.4
Risultati analitici
C6 is depleted by immunoadsorption as judged by a highly sensitive hemolytic assay.
Esclusione di responsabilità
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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Molecular basis for complement component 6 (C6) deficiency in rats and mice.
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M R Haeney et al.
Clinical and experimental immunology, 40(1), 16-24 (1980-04-01)
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The clinical outcomes of primary immunodeficiencies (PIDs) are greatly improved by accurate diagnosis early in life. However, it is not common to consider PIDs before the manifestation of severe clinical symptoms. Including PIDs in the nation-wide newborn screening programs will
Kelly L Parham et al.
Molecular immunology, 44(10), 2756-2760 (2007-01-30)
Complement component C6 is one of five terminal complement components incorporated into the membrane attack complex. Complete deficiency of C6 (C6Q0) leads to an increased susceptibility to Neisseria meningitidis infections, and affected individuals typically present with recurrent meningococcal disease. There
Cryo-EM structures of Trypanosoma brucei gambiense ISG65 with human complement C3 and C3b and their roles in alternative pathway restriction.
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