H7789

Anti-acetyl-Histone H1.4 (AcLys²⁶)

affinity isolated antibody, buffered aqueous solution

• Sinonimo/i: Anti-H1 Histone family, member 4, Anti-H1e, Anti-Histone 1, Anti-Histone H1b
• Numero MDL: MFCD09753843
• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Coniugato: unconjugated
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Stato: buffered aqueous solution
• PM: antigen ~35 kDa
• Reattività contro le specie: human
• tecniche: western blot: 0.5-1 μg/mL using acid-extracted fraction of HL60 cells
• N° accesso UniProt: P10412
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: acetylation (Lys26)
• Informazioni sul gene: human ... HIST1H1E(3008)

Descrizione

Descrizione generale

In mammalian cells, four histone H1 variants (H1.2 to H1.5) are present in all somatic cells, and a fifth (H1.1) is restricted to thymus, testis, and spleen and possibly lymphocytic and neuronal cells. Histone H1.4 is di-methylated or acetylated at Lys26. Lys26 is located within the flexible N-terminal domain of H1.4, just preceding the globular domain.

Immunogeno

synthetic acetylated peptide corresponding to amino acids 22-33 (Ac-Lys²⁶) of human histone H1.4.

Applicazioni

Anti-acetyl-Histone H1.4 (Ac-Lys26) antibody produced in rabbit is suitable for western blot at a concentration of 0.5-1μg/mL using acid-extracted fraction of HL60 cells.

Anti-acetyl-Histone H1.4 (Ac-Lys²⁶) antibody produced in rabbit has been used in western blotting.

Azioni biochim/fisiol

H1.4 at lysine residue 26 represses transcription. Linker histone H1 binds to DNA between nucleosomal core particles and is involved in establishing and maintaining higher order chromatin structures. Histone modifications are thought to play an important role in cancer and disease.

Stato fisico

Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)